To demonstrate wether there is difference in tissue oxygen tension and extravascular lung water while patients are being resuscitated with cristalloids or colloids combined with cristalloids.
ID
Bron
Verkorte titel
Aandoening
Severe sepsis or septic shock.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The relation between the resuscitation regime and the tissue oxygen tension. <br>Furthermore the relation between the resuscitation regime and the amount of extravascular lungwater, as well as the relation between the amount of extravascular lungwater and the tissue oxygen tension.
Achtergrond van het onderzoek
N/A
Doel van het onderzoek
To demonstrate wether there is difference in tissue oxygen tension and extravascular lung water while patients are being resuscitated with cristalloids or colloids combined with cristalloids.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
Subjects are assigned to be resuscitated either with cristalloids (sodiumchloride 0,9%) or cristalloid combined with colloids (polyhydroxyethylstarch 10%) untill rescusitation endpoints have been established.
Endpoints are an intrathoracal blood volume of > 850 ml/m2, a mean arterial pressure of > 70 mmHg and a cardiac index of > 3.0 l/min/m2.
Publiek
Department of Surgery, HP G04.228,
P.O. Box 85500
L.P.H. Leenen
Heidelberglaan 100
Utrecht 3584 CX
The Netherlands
+31 (0)30 2509882
lleenen@chir.azu.nl
Wetenschappelijk
Department of Surgery, HP G04.228,
P.O. Box 85500
L.P.H. Leenen
Heidelberglaan 100
Utrecht 3584 CX
The Netherlands
+31 (0)30 2509882
lleenen@chir.azu.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Sever sepsis or septic shock (according to the criteria of the American College of Chest Physicians / Society of Critical Care Medicine) in a mechanically ventilated ICU patient.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Patients under the age of 18 years and patients with a sensitivity to starch-products.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
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Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL460 |
| NTR-old | NTR501 |
| Ander register | : N/A |
| ISRCTN | ISRCTN25391663 |