Interindividual variation in antihypertensive drug response can be predicted through lifestyle, demographics and plasma drug levels.
ID
Bron
Verkorte titel
Aandoening
6 week periods of antihypertensive drug treatment in monotherapy with 3 weeks washout. Drugs: A lisinopril B nebivolol C barnidipine D HCl thiazide E eprosartan.
Ondersteuning
Yamanouchi Benelux
Solvay Benelux
by sponsors
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. Office blood pressure measured with an automatic device; <br>
2. Side effects measured with a questionnaire.<br>
Achtergrond van het onderzoek
The choice of antihypertensive drugs for individual patients is difficult. We try to make a predictive model depending on class effects of the 5 amin anti-hypertensive drug classes that can later be tested prospectively. The etnic groups in teh trial have been explicitely defined in advance.
Doel van het onderzoek
Interindividual variation in antihypertensive drug response can be predicted through lifestyle, demographics and plasma drug levels.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
6 week periods of antihypertensive drug treatment in monotherapy with 3 weeks washout. Drugs: A lisinopril B nebivolol C barnidipine D HCl thiazide E eprosartan.
Publiek
P.O. Box 22660
R.P. Koopmans
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5669111
r.p.koopmans@amc.uva.nl
Wetenschappelijk
P.O. Box 22660
R.P. Koopmans
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5669111
r.p.koopmans@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Subjects with uncomplicated hypertension between the ages of 36 and 60 years.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Serious hypertensive organ damage
co-morbidity.
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL344 |
| NTR-old | NTR384 |
| Ander register | : N/A |
| ISRCTN | ISRCTN08931855 |