By combining advanced modalities, a comprehensive model can be built for a better prediction of progression in MS.
ID
Bron
Verkorte titel
Aandoening
Multiple Sclerosis
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Our primary outcome is longitudinal cognitive decline, as measured by neuropsychological assessment (NPE).
Achtergrond van het onderzoek
Single-center observational study, in which patients with MS and healthy controls who have previously participated in longitudinal studies at the MS Center Amsterdam are invited for a repeat visit, referred to as "Amsterdam MS cohort - round 2021". This will result in an unprecedented longitudinal MS cohort with advanced measurements (clinical, imaging and body fluid biomarkers) at three time points, roughly five years apart. The objective is to study underlying mechanisms of cognitive decline and clinical progression in MS and ultimately improve our understanding and prediction of clinical outcomes.
Doel van het onderzoek
By combining advanced modalities, a comprehensive model can be built for a better prediction of progression in MS.
Onderzoeksopzet
Follow-up visit approximately 10-15 years after first observation (initiated at varying stages of the disease)
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
All people with MS and all healthy controls who have previously participated in the Presto (local ethics committee number: 2002/140), GeneOCT (2004/9), or LTD (2010/336) studies (collectively also known as the “Amsterdam MS Cohort”) and have not provided objection to be contacted for follow-up study, or have been enquired to join the cohort based on the Amsterdam MS Cohort (2020/269) protocol.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
MS patients unable to undergo the minimal data collection (as described in Methods section) or comorbidity that interferes with participation in this study (controls).
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL9409 |
| Ander register | METC VUmc : 2020.0601 |