Supplementation with pyridoxine-5'-phosphate will not lead to an increase in plasma concentrations of pyridoxine
ID
Bron
Aandoening
pharmacokinetics, pyridoxine, pyridoxal-5'-phosphate
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
plasma pyridoxine concentration during 4 h after the first inake (pharmacokinetics, AUC), and at days 3 and 7 of the study
Achtergrond van het onderzoek
In this study the pharmacokinetics of 50 mg pyridoxal-5'-phosphate after oral intake by adult, healthy volunteers, and after daily supplementation with 50 mg during 3 and 7 days plasma B6 vitamers will be determined. This will be compared to daily intake of 50 mg of pyridoxine. Plasma concentrations of pyridoxine and other relevant B6 vitamers will be analysed.
Doel van het onderzoek
Supplementation with pyridoxine-5'-phosphate will not lead to an increase in plasma concentrations of pyridoxine
Onderzoeksopzet
day 1: before intake, and 30 min, 60 min, 90 min, 120 min, 150 min, 180 min, 210 min and 240 min after intake
day 3
day 7
Onderzoeksproduct en/of interventie
daily intake of 50 mg of pyridoxal-s'-phosphate or 50 mg pyridoxine (active control) during 7 days
Publiek
Geja J. Hageman
Maastricht 6200 MD
The Netherlands
g.hageman@maastrichtuniversity.nl
Wetenschappelijk
Geja J. Hageman
Maastricht 6200 MD
The Netherlands
g.hageman@maastrichtuniversity.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
healthy, adults, both male and female, aged between 20 and 50 years with normal liver and kidney function, with normal BMI (between 19 and 25), and able to come to the research laboratory on 3 specified occasions within a one week period
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
use of medication (with the exception of oral contraceptives), use of vitamin supplements during the past 6 months, detectable plasma level of pyridoxine, non-normal liver and kidney functions, BMI <19 or >25, alcohol consumption > 2 drinks/day
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL6105 |
| NTR-old | NTR6446 |
| Ander register | METC163051 : Universiteit Maastricht |