Increased and improved mastication will improve (or, slow down the loss of) cognition, mood and circadian rhythm of elderly people suffering from dementia.
ID
Bron
Verkorte titel
Aandoening
dementia, cognition, depression, circadian rhythm, mastication, exercise
dementie, cognitie, depressie, slaap-waakritme, kauwen, bewegen
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Improved quality of life.
Achtergrond van het onderzoek
Exercise is thought to be beneficial for prevention and treatment of cognitive problems, mood disorders and circadian rhythm disturbances in elderly suffering from dementia.
Improved cardiovascular health and increased brain perfusion are considered to be explanatory mechanisms for this effect.
Mastication induces similar bodily responses as exercise, such as increased heart rate, blood pressure and brain perfusion.
Furthermore, impaired mastication (by means of removal of the molar teeth or by offering soft food) negatively effects the performance of mice in maze tasks, and leads to hippocampal neuron loss. Since the hippocampus is associated with both spatial orientation and memory, these findings indicate that impaired mastication leads to memory loss, amongst others. In humans, correlations have been found between mastication and memory, attention and performance on several executive functioning tasks; i.e. when chewing a piece of gum the performance improves.
Doel van het onderzoek
Increased and improved mastication will improve (or, slow down the loss of) cognition, mood and circadian rhythm of elderly people suffering from dementia.
Onderzoeksopzet
Base line at 0 weeks;
Follow up at 6 weeks, 3 months, and 6 months.
Onderzoeksproduct en/of interventie
Intervention-Increased masticatory activity achieved through improved oral health care and diet.
Publiek
Room 1F-58
Roxane Weijenberg
Boechorststraat 1
Amsterdam 1081 BT
The Netherlands
+31 (0)20 5988988
raf.weijenberg@psy.vu.nl
Wetenschappelijk
Room 1F-58
Roxane Weijenberg
Boechorststraat 1
Amsterdam 1081 BT
The Netherlands
+31 (0)20 5988988
raf.weijenberg@psy.vu.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Older than 50 years; suffering from dementia.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. History of psychiatric disorder
2. Alcohol abuse
3. Cerebral traumata
4. Normal pressure hydrocephalus
5. Neoplasmata
6. Conscious disorders
Opzet
Deelname
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In overige registers
Register | ID |
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NTR-new | NL1491 |
NTR-old | NTR1561 |
Ander register | VU University Medical Center : 2504931 |
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