To gain more insight into the pathogenetic processes involved in Sjogrens Syndrome(SS) bij analyzing the infiltrate and structural changes in salivary glands of SS patients and compare these findings to those in other (aspecific) inflammatory and…
ID
Bron
Verkorte titel
Aandoening
Sjogrens Syndroom
auto-immuun aandoeningen
Xerostomie
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Obtained material will be used to elucidate primarily the B-cell pathogenesis of Sjogren's Syndrome. Using immunohistochemistry, RNS and protein analysis, the B-cel receptor (BCR), T-cell receptor (TCR), a B-cell stimulating cytokine (APRIL) and the interaction between different immune cell populations and cytokines will be studied
Achtergrond van het onderzoek
Country of recruitment: The Netherlands.
In all patients undergoing diagnostic lower lip biopsies, salivary gland tissue will be collected and studied.
Doel van het onderzoek
To gain more insight into the pathogenetic processes involved in Sjogrens Syndrome(SS) bij analyzing the infiltrate and structural changes in salivary glands of SS patients and compare these findings to those in other (aspecific) inflammatory and non-inflammatory salivary gland diseases.
Onderzoeksopzet
One, after lipbiopsy.
Onderzoeksproduct en/of interventie
In all patients undergoing diagnostic lower lip biopsies, salivary gland tissue will be collected and processed using a standard protocol for formalin fixation to allow standard histological evaluation for diagnostic purposes. Samples will also be frozen in Tissue-Tek OCT compound for immunohistochemistry (IHC) or snap frozen for PCR, micro-array, T Cell Receptor (TCR) and B Cell Receptor (BCR) analysis, and protein expression analysis. Tissues will be analyzed using these techniques for exploratory analysis in relationship to the pathogenesis of SS.
Publiek
P.O. Box 22660
P.P. Tak
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5662171
p.p.tak@amc.nl
Wetenschappelijk
P.O. Box 22660
P.P. Tak
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5662171
p.p.tak@amc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Patients undergoing lower lip biopsies for diagnostic purposes.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
N/A
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL2339 |
| NTR-old | NTR2446 |
| Ander register | MEC AMC : 10/011 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |