We hypothesize that 18F-FDG is a valide marker for metabolic activity in adipose tissue and even more pronounced in type 2 diabetes.
ID
Bron
Verkorte titel
Aandoening
Type 2 diabetes
Obesity
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
• Compared associations between CVD risk factors and abdominal adipose tissue volume<br>
• The association between abdominal adipose tissue and arterial inflammation <br>
• 18F-FDG adipose tissue uptake differences between VAT and SAT
Achtergrond van het onderzoek
Already early in the course of their disease, patients with type 2 diabetes (T2D) have considerably increased cardiovascular risk, irrespective of glycemic control. Visceral adipose tissue (VAT) is thought to play an important role, by inducing insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD) and by being metabolically active and producing adipocytokines. Its contribution to early atherosclerosis development is not fully understood. We investigated the association between VAT volume and subclinical arterial inflammation in early T2D patients by using 18F-fluordeoxyglucose (FDG) positron emission tomography (PET) with low dose computed tomography (CT) and performed a pilot to explore the value of FDG-uptake in VAT as a proxy for its metabolic activity.
Furthermore, to study whether VAT in diabetic subjects is inflamed, ex vivo 18F-FDG uptake will be determined using PET and compared with uptake in VAT and SAT.
Doel van het onderzoek
We hypothesize that 18F-FDG is a valide marker for metabolic activity in adipose tissue and even more pronounced in type 2 diabetes.
Onderzoeksopzet
T0= informed consent
T1= venapuncture and 18F-FDG PET/CT scan
Onderzoeksproduct en/of interventie
Not applicable
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Men and woman
- Age above 17 years
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Age below 18 years
- Incompetent
- Type 1 diabetes
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL7445 |
| NTR-old | NTR7687 |
| Ander register | Research register UMCG : 201700731 |
Samenvatting resultaten
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2: Effect of Linagliptin on Arterial 18F-Fluorodeoxyglucose Positron Emission Tomography Uptake: A Randomized Controlled Trial (RELEASE). de Boer SA, Heerspink HJ, Lefrandt JD, Hovinga-de Boer MC, van Roon AM, Juárez Orozco LE, Glaudemans AW, Kamphuisen PW, Slart RH, Mulder DJ. J Am Coll Cardiol. 2017 Feb 28;69(8):1097-1098. doi: 10.1016/j.jacc.2016.12.018