The administered protein mix is related to a faster postprandial amino acid bioavailability compared to a single protein as measured by the t½ of the iAUC.
ID
Bron
Verkorte titel
Aandoening
Healthy older subjects (age 65 years or older)
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The primary outcome parameter in this study is the time to reach half incremental area under the curve (t½ iAUC) for the sum of all amino acids (total AA) comparing product A to product B.
Achtergrond van het onderzoek
The purpose of the current study is to gain knowledge regarding amino acid bioavailability of different proteins and protein mixes.
Secondly, we aim to study the impact of different proteins on gastric emptying and postprandial fullness and satiety.
This is a randomized, controlled, double-blind, crossover, single-centre study which aims to include 13 healthy older subjects (age 65 years or older) with a minimum of 4 subjects for each sex.
Six different study products will be investigated:
- 4 seperate proteins
- two mixes of these proteins
Doel van het onderzoek
The administered protein mix is related to a faster postprandial amino acid bioavailability compared to a single protein as measured by the t½ of the iAUC.
Onderzoeksopzet
Time points of the outcome: V1 (baseline) until V6 (week 6).
Onderzoeksproduct en/of interventie
Duration of intervention: 5 weeks
Intervention group: 5 weeks
Control group: 5 weeks
Publiek
Zandrie Hofman
PO Box 80141
Utrecht 3508 TC
The Netherlands
+31-30-2095000
zandrie.hofman@danone.com
Wetenschappelijk
Zandrie Hofman
PO Box 80141
Utrecht 3508 TC
The Netherlands
+31-30-2095000
zandrie.hofman@danone.com
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Age 65 years or older
2. BMI from 20 through 30 kg/m2
3. Willingness and ability to comply with the protocol
4. Written informed consent
5. Be judged by the investigator to be in good health
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Any gastrointestinal (GI) disease or surgery that interferes with GI function
2. Known renal or hepatic failure
3. Known or suspected Diabetes Mellitus (fasting glucose level ¡Ý 7.0 mmol/L)
4. (History of) any cancer with the exception of basal cell carcinoma
5. Fever in the last 7 days prior to Visit 1
6. Haemoglobin in men <7.5 mmol/L and in women <7.0 mmol/L
7. Use of antibiotics, or anticonvulsants, or prokinetics, or antacids or any medication influencing gastric acid production, or oral and systemic use of anticoagulants, or corticosteroids, or laxatives, or growth hormone, or testosterone, or immunosuppressants or insulin within 3 weeks of Visit 1
8. Known severe weight loss (> 3 kg in last 3 months)
9. Participation to a weight loss program
10. Use of protein containing or amino acid containing nutritional supplements within one week of Visit 1
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5311 |
| NTR-old | NTR5420 |
| Ander register | : NTS.1.P/H, Nutricia Research B.V. |