1. does pseudophakia influence intra ocular pressure (IOP) lowering effect of SLT? 2. the effect of SLT relies on an inflammatory reaction. Anti-inflammatory therapy is often used immediately following SLT, does this influence the IOP lowering…
ID
Bron
Verkorte titel
Aandoening
many local and systemic side effects of anti glaucoma eye drops can be eliminated by using laser and reducing eye drops
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1, IOP lowering effect of SLT
Achtergrond van het onderzoek
Glaucoma is a very common chronic disease. Selective laser trabeculoplasty (SLT) has the advantage of eliminating the side effects that are very common after using anti-glaucoma eye drops. We aim to investigate several aspects of SLT
Doel van het onderzoek
1. does pseudophakia influence intra ocular pressure (IOP) lowering effect of SLT?
2. the effect of SLT relies on an inflammatory reaction. Anti-inflammatory therapy is often used immediately following SLT, does this influence the IOP lowering effect or the side effects after SLT?
3. anti-glaucoma eye drops have a lot of side effects. Does SLT improve quality of life by reducing number of eye medications?
4. is there a significant difference in IOP lowering effect of SLT in low, normal or high tension glaucoma?
Onderzoeksopzet
start, 1 hour, 1 week, 1, 3, 6 and 12 months after SLT
Onderzoeksproduct en/of interventie
1,Randomization decides whether patients receive SLT or continue on drops.
2,In those to receive SLT, randomization decides whether indomethacin or dexamethasone drops are given after SLT.
3,SLT is applied in both eyes, randomization decides in which eye the anti-inflammatory therapy (indomethacin or dexamethasone) is given, we start SLT always at the right eye.
4, SLT is performed, right eye first, the week after that, the other eye is treated. Eye that does not receive anti-inflammatory therapy is control eye.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
patients with ocular hypertension or chronic open angle glaucoma controlled by medical therapy. Patients had to be prepared to sign an informed consent document.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
other types of glaucoma than open angle glaucoma, previous trabeculectomy or selective laser trabeculoplasty. Corneal disease that inhibit good visualization of the trabecular meshwork and patients taking systemic steroids are excluded
Opzet
Deelname
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