The beneficial effect of cold acclimation on insulin sensitivity is reproducible and the effect wil sustain for a longer period of time. Besides insulin sensitivity, cold acclimation also has beneficial effects on cardiovascular risk factors in type…
ID
Bron
Aandoening
Cold acclimation
Non insulin depended diabetes mellitus
Insulin sensitivity
Obesitas (BMI 28-35)
Cardiovascular risks
Lipid metabolism
Insulinegevoeligheid
Koude acclimatie
Overgewicht
Diabetes mellitus type 2
Vetmetabolisme
cardiovasculair risico
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
- Insulin sensitivity as determined by hyperinsulinemic euglycemic clamp. <br>
- Metabolism of triglyceride, cholesterol and lipoproteins after a meal.
Achtergrond van het onderzoek
Type 2 diabetes is a major health problem and is accompanied with increased cardiovascular disease risk. Cold exposure has received much attention over the past years as a potential strategy to improve metabolic health. It has previously been shown that 10 days of cold acclimation markedly improved skeletal muscle insulin sensitivity in patients with type 2 diabetes. However, whether cold acclimation also affects postprandial metabolism and cardiovascular risk markers remains unknown. We aimed to investigate whether cold acclimation beneficially affected postprandial metabolism and cardiovascular risk markers, and if the effect on insulin sensitivity was sustained for a longer period of time.
Doel van het onderzoek
The beneficial effect of cold acclimation on insulin sensitivity is reproducible and the effect wil sustain for a longer period of time. Besides insulin sensitivity, cold acclimation also has beneficial effects on cardiovascular risk factors in type 2 diabetes.
Onderzoeksopzet
- Insulin sensitivity: day 4, 19 and 29
- Lipid metabolism: day 1 and 16
- Endothelial and vascular function: day 1 and 16
- Muscle biopsy: day 4, 19 and 29
- Intrahepatic lipid content: day 4 and 19
- Skin temperature: day 6, 8 and 15
- Thermal sensation and comfort: day 6-15
- Endothelial/inflammatory markers; energy metabolism markers: day 1 and 16; day 4 and 19
- Mean glycosylated hemoglobin A1C: day 83
Onderzoeksproduct en/of interventie
Cold acclimation by staying ten days in a climate chamber of 16 °C
Publiek
Michiel Moonen
Maastricht
The Netherlands
043-43384259
m.moonen@maastrichtuniversity.nl
Wetenschappelijk
Michiel Moonen
Maastricht
The Netherlands
043-43384259
m.moonen@maastrichtuniversity.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Caucasians
- Age: 45 – 70 years
- BMI: 28-35 kg/m2
- Gender: male or female
- Women should be postmenopausal
- Diagnosed with type 2 diabetes at least 1.5 years before the start of the study
- Relatively well-controlled type 2 diabetes: HbA1c < 8.5%
- Oral glucose lowering medication (metformin only or in combination with sulfonylurea agents)
- No signs of active diabetes-related co-morbidities like active cardiovascular diseases, active diabetic foot, polyneuropathy or retinopathy.
- No signs of active liver or kidney malfunction.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Participate in physical activity more than 2x/week
- Unstable body weight (weight gain or loss > 5 kg in the last three months)
- Participation in another biomedical study concerning brown adipose tissue within 1 month before the first screening visit
- Insulin dependent type 2 diabetes patients
- Smoking
- Men: Hb <8.4 mmol/L, Women: Hb <7.8 mmol/l
Opzet
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| Register | ID |
|---|---|
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