Short-term (1-year) results of renal transplantation are now excellent (over 95%). Long-term (10-year and longer) results are, however, still disappointing. Where most research has focused on immunosuppression and infections, we hypothesize that due…
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Verkorte titel
Aandoening
Short-term (1-year) results of renal transplantation are now excellent (over 95%). Long-term (10-year and longer) results are, however, still disappointing. Where most research has focused on immunosuppression and infections, we hypothesize that due to poor homeostatic capacity and necessary use of immunosuppressive and other drugs, renal transplant recipients are much more susceptible to poor dietary habits and exposure to potentially toxic contaminants than people of the general population, and that this contributes to accelerated function loss of the graft and excess risk of premature mortality, both contributing to poor long-term results.
To investigate one part of this overarching hypothesis we wrote a project on around the specific topic of the relation between dietary acid load, ammoniagenesis and its potential influence on blood pressure. We used this project to build a biobank and cohort in which we can test additional hypotheses on the relation between diet, contaminants and development of graft failure and the occurrence of mortality.
We also included 300 healthy controls to compare diet, contaminant exposure and biomarkers with the renal transplant recipients.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Graft failure and all-cause mortality
Achtergrond van het onderzoek
The baseline measurements of the cohort have been performed between 21-11-2008 and 24-05-2011. In this time, 707 renal transplant recipients and 300 healthy potential living kidney donors have been included. The baseline measurements were complemented with a biobank of serum, plasma and 24h urine samples stored at -80 degrees Centigrade. Included participants are now prospectively followed for development of outcome events.
Doel van het onderzoek
Short-term (1-year) results of renal transplantation are now excellent (over 95%). Long-term (10-year and longer) results are, however, still disappointing. Where most research has focused on immunosuppression and infections, we hypothesize that due to poor homeostatic capacity and necessary use of immunosuppressive and other drugs, renal transplant recipients are much more susceptible to poor dietary habits and exposure to potentially toxic contaminants than people of the general population, and that this contributes to accelerated function loss of the graft and excess risk of premature mortality, both contributing to poor long-term results. This study is a biobank and cohort study which investigates this hypothesis.
Onderzoeksopzet
Baseline measurements
Routine outpatient clinical visits
Onderzoeksproduct en/of interventie
No interventions, the cohort is observational
Publiek
S.J.L. Bakker
Hanzeplein 1
Groningen 9713 GZ
The Netherlands
+31-50-3616161
s.j.l.bakker@umcg.nl
Wetenschappelijk
S.J.L. Bakker
Hanzeplein 1
Groningen 9713 GZ
The Netherlands
+31-50-3616161
s.j.l.bakker@umcg.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
More than one year after transplantation, prognosis > 1 year, stable outpatients situation
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Acute illnesses, fever, current hospitalisation
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5673 |
| NTR-old | NTR5910 |
| Ander register | TransplantLines Food and Nutrition : METc2008/186 |
Samenvatting resultaten
Berg E, van Goor H, Bakker SJ, Tsikas D. High urinary homoarginine excretion is
associated with low rates of all-cause mortality and graft failure in renal
transplant recipients. Amino Acids. 2015 Sep;47(9):1827-36. doi:
10.1007/s00726-015-2038-6. Epub 2015 Jul 5. PubMed PMID: 26142633.
<br><br>
2: Frenay AR, van den Berg E, de Borst MH, Beckmann B, Tsikas D, Feelisch M,
Navis G, Bakker SJ, van Goor H. Plasma ADMA associates with all-cause mortality
in renal transplant recipients. Amino Acids. 2015 Sep;47(9):1941-9. doi:
10.1007/s00726-015-2023-0. Epub 2015 Jun 16. PubMed PMID: 26077715; PubMed
Central PMCID: PMC4549386.
<br><br>
3: Keyzer CA, de Borst MH, van den Berg E, Jahnen-Dechent W, Arampatzis S, Farese
S, Bergmann IP, Floege J, Navis G, Bakker SJ, van Goor H, Eisenberger U, Pasch A.
Calcification Propensity and Survival among Renal Transplant Recipients. J Am Soc
Nephrol. 2016 Jan;27(1):239-48. doi: 10.1681/ASN.2014070670. Epub 2015 Apr 29.
PubMed PMID: 25925688; PubMed Central PMCID: PMC4696561.
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4: Baia LC, Van den Berg E, Vervloet MG, Heilberg IP, Navis G, Bakker SJ,
Geleijnse JM, Kromhout D, Soedamah-Muthu SS, De Borst MH; NIGRAM consortium. Fish
and omega-3 fatty acid intake in relation to circulating fibroblast growth factor
23 levels in renal transplant recipients. Nutr Metab Cardiovasc Dis. 2014
Dec;24(12):1310-6. doi: 10.1016/j.numecd.2014.06.006. Epub 2014 Jun 23. PubMed
PMID: 25063539.
<br><br>
5: Zittema D, van den Berg E, Meijer E, Boertien WE, Muller Kobold AC, Franssen
CF, de Jong PE, Bakker SJ, Navis G, Gansevoort RT. Kidney function and plasma
copeptin levels in healthy kidney donors and autosomal dominant polycystic kidney
disease patients. Clin J Am Soc Nephrol. 2014 Sep 5;9(9):1553-62. doi:
10.2215/CJN.08690813. Epub 2014 Jul 3. PubMed PMID: 24993447; PubMed Central
PMCID: PMC4152815.
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6: van den Berg E, Pasch A, Westendorp WH, Navis G, Brink EJ, Gans RO, van Goor
H, Bakker SJ. Urinary sulfur metabolites associate with a favorable
cardiovascular risk profile and survival benefit in renal transplant recipients.
J Am Soc Nephrol. 2014 Jun;25(6):1303-12. doi: 10.1681/ASN.2013050497. Epub 2014
Feb 7. PubMed PMID: 24511127; PubMed Central PMCID: PMC4033367.
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7: Snijder PM, van den Berg E, Whiteman M, Bakker SJ, Leuvenink HG, van Goor H.
Emerging role of gasotransmitters in renal transplantation. Am J Transplant. 2013
Dec;13(12):3067-75. doi: 10.1111/ajt.12483. Epub 2013 Oct 30. Review. PubMed
PMID: 24266966.
<br><br>
8: Boxma PY, van den Berg E, Geleijnse JM, Laverman GD, Schurgers LJ, Vermeer C,
Kema IP, Muskiet FA, Navis G, Bakker SJ, de Borst MH. Vitamin k intake and plasma
desphospho-uncarboxylated matrix Gla-protein levels in kidney transplant
recipients. PLoS One. 2012;7(10):e47991. doi: 10.1371/journal.pone.0047991. Epub
2012 Oct 31. PubMed PMID: 23118917; PubMed Central PMCID: PMC3485347.
<br><br>
9: van den Berg E, Engberink MF, Brink EJ, van Baak MA, Joosten MM, Gans RO,
Navis G, Bakker SJ. Dietary acid load and metabolic acidosis in renal transplant
recipients. Clin J Am Soc Nephrol. 2012 Nov;7(11):1811-8. doi:
10.2215/CJN.04590512. Epub 2012 Aug 30. PubMed PMID: 22935845; PubMed Central
PMCID: PMC3488949.
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10: van den Berg E, Engberink MF, Brink EJ, van Baak MA, Gans RO, Navis G, Bakker
SJ. Dietary protein, blood pressure and renal function in renal transplant
recipients. Br J Nutr. 2013 Apr 28;109(8):1463-70. doi:
10.1017/S0007114512003455. Epub 2012 Aug 21. PubMed PMID: 22906209.
<br><br>
11: van den Berg E, Geleijnse JM, Brink EJ, van Baak MA, Homan van der Heide JJ,
Gans RO, Navis G, Bakker SJ. Sodium intake and blood pressure in renal transplant
recipients. Nephrol Dial Transplant. 2012 Aug;27(8):3352-9. doi:
10.1093/ndt/gfs069. Epub 2012 Apr 12. PubMed PMID: 22499024.