Laparoscopic Fluorescent near-infrared imaging using ICG can accurately detect liver metastases from uveal melanoma intra operatively.
ID
Bron
Verkorte titel
Aandoening
Hepatic Uveal Melanoma Metastases
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Feasiility of Intra-operative identification of liver metastases.
Achtergrond van het onderzoek
One of the main challenges in liver surgery for uveal liver metastasis is intraoperative tumor detection. Especially intra-operative detection of small tumors has proven to be very difficult. Near-infrared fluorescent (NIRF) imaging is a recently developed method to visualize tumor tissue during surgery. Standard liver resection will be performed. The near-infrared dye ICG will be injected i.v. and liver tumors will be visualized using a laparoscopic NIRF imaging system.
Doel van het onderzoek
Laparoscopic Fluorescent near-infrared imaging using ICG can accurately detect liver metastases from uveal melanoma intra operatively.
Onderzoeksopzet
The primary and secondary outcomes will be assessed during surgery and pathological assessment.
Onderzoeksproduct en/of interventie
ICG will be administered 24hours before surgery. During laparoscopic surgery, liver metastases will be visualised using near-infrared fluorescence imaging and standard liver resection will be performed.
Publiek
Department of Surgical Oncology,
P.O. Box 9600
C.J.H. Velde, van de
Leiden 2300 RC
The Netherlands
+31 (0)71 5262309
c.j.h.van_de_velde@lumc.nl
Wetenschappelijk
Department of Surgical Oncology,
P.O. Box 9600
C.J.H. Velde, van de
Leiden 2300 RC
The Netherlands
+31 (0)71 5262309
c.j.h.van_de_velde@lumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Patients diagnosed with uveal melanoma liver metastasis that are eligible for resection;
2. Age between 18 and 80 years old.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. No history of allergy to iodine, shellfish, indocyanine green, human serum albumin and/or history of hyperthyroidism or severe renal impairment;
2. Patient pregnant or lactating.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL3700 |
| NTR-old | NTR3869 |
| Ander register | METC LUMC : P10.001 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |