OncoLifeS Oncological Life Study: Living well as a cancer survivor

OncoLifeS is a hospital-based data-biobank for oncology, that links routine clinical data of patients with preserved biological specimens and quality of life assessments. The aim of the OncoLifeS is to provide an infrastructure including a protected environment for studying cancer biomarkers, treatment response, and treatment effects on different patient outcomes and quality of life. Inclusion to the OncoLifeS data-biobank is prospective and on an ongoing basis. All adult patients (>18 years of age) diagnosed with cancer or with a genetically increased risk of cancer are being included, without further exclusions. Informed consent is obtained from patients before inclusion, and the data collection is embedded within routine care. Data are collected on patient and disease characteristics including clinical and treatment details, comorbidities, lifestyle, radiological and pathological findings, and long-term outcomes. Several biomaterials are routinely collected and stored for future use: serum, ethylenediaminetetraacetic acid (EDTA) plasma, heparin-plasma + buffy coat (DNA), DNA (by whole blood collected in EDTA tubes), plasma for cell-free DNA (by whole blood collected in Streck tubes), RNA (by whole blood collected in PAXgene tubes), bone marrow, feces, urine, tumor tissue, and healthy tissue. In addition, patient-reported data are collected via questionnaire at baseline, including data on family history of cancer, lifestyle, social status, quality of life, and comorbidities. For patients aged 65 years and older, it also includes evaluations of daily living activities and frailty. Data on quality of life are collected at baseline and at 6, 12, 18, and 24 months after the start of treatment. It is possible to link our data to other Dutch registries and databases.

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According to clinically meaningful visits frequency

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