The use of paracetamol reduces total opioid requirement in the ED and during the first 24 hours.
ID
Bron
Aandoening
Opioid use, pain
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The main study endpoint is the opioid requirement in Morphine Equivalent Units (MEU) between individual subjects who received additional paracetamol and those who did not.
Achtergrond van het onderzoek
Rationale:
In 2013 about 1.8 million patients visited an ED in the Netherlands, of whom approximately 30.000 attended the AMC. About 50-79% of all patients in the ED complained about pain, and in approximately 40% of these patients, pain was not treated properly.
Of all therapeutically used drugs, opioid analgesics are most frequently associated with adverse drug events. Combining drugs with different mechanisms of action may have an additive or synergistic effect and may lead to a reduction in adverse events. Adjacent paracetamol showed a decrease of approximately 20 to 25% in opioid requirements, postoperatively.
Doel van het onderzoek
The use of paracetamol reduces total opioid requirement in the ED and during the first 24 hours.
Onderzoeksopzet
-
Onderzoeksproduct en/of interventie
-
Publiek
Afdeling Spoedeisende Geneeskunde
Academisch Medisch Centrum
Meibergdreef 9
M.L. Ridderikhof
Amsterdam 1105 AZ
The Netherlands
020-5663333
M.L.Ridderikhof@amc.uva.nl
Wetenschappelijk
Afdeling Spoedeisende Geneeskunde
Academisch Medisch Centrum
Meibergdreef 9
M.L. Ridderikhof
Amsterdam 1105 AZ
The Netherlands
020-5663333
M.L.Ridderikhof@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
In order to be eligible to participate in this study, a subject must meet all of the following criteria:
- patients 18 years or older presenting to the ED in the AMC
- an NRS of 4 or higher during presentation
- patients having received an opioid prehospitally (usually in the ambulance) or in the ED
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
A potential subject who meets any of the following criteria will be excluded from participation in this study:
- hepatic dysfunction
- not capable of reporting their NRS during presentation
- chronic use of analgesics
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL6572 |
| NTR-old | NTR6958 |
| Ander register | : W18_015. METC, AMC, Amsterdam |