Organoids can be cultured from pancreatic ductal biopsies, obtained from chronic pancreatitis patients, to study electrolyte and fluid secretion.
ID
Bron
Verkorte titel
Aandoening
Pancreatitis
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The ability to culture PDEC organoids from pancreatic duct biopsies.
Achtergrond van het onderzoek
Pancreatitis is a common cause of hospitalization, with no specific therapy available other than supportive care. Recent evidence indicates that the loss of electrolyte and fluid secretion by pancreatic ductal epithelial cells (PDECs) is a key factor in the etiology of pancreatitis. In particular, dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) has been associated with pancreatitis. We hypothesize that organoids can be cultured from pancreatic ductal biopsies, obtained from chronic pancreatitis patients, to study electrolyte and fluid secretion. The potential role of ion transport abnormalities in the etiology of pancreatitis will be investigated in pancreatic and intestinal (duodenal) organoids, the latter an established model to study CFTR function.
Doel van het onderzoek
Organoids can be cultured from pancreatic ductal biopsies, obtained from chronic pancreatitis patients, to study electrolyte and fluid secretion.
Onderzoeksopzet
Collection will be performed during pancreatoscopy.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
All patients undergoing pancreatoscopy within the framework of regular diagnostics or treatment.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
A potential subject that is younger than 18 years old will be excluded from participation in this study.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL9772 |
| Ander register | METC Erasmus MC : MEC-2021-0737 |