The aerobic pre-conditioning will increase muscle perfusion and thereby improve muscle hypertrophy during the subsequent resistance training program.
ID
Bron
Verkorte titel
Aandoening
Sarcopenia
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
• Type II muscle fiber size (muscle biopsy)
Achtergrond van het onderzoek
Aging is accompanied by the loss of muscle mass, resulting in a decrease in overall health and function in seniors. This loss can partly be explained by an age-related reduction in muscle perfusion. This study will investigate if endurance exercise training can restore the impaired muscle perfusion to improve muscle mass maintenance and health in older adults.
Doel van het onderzoek
The aerobic pre-conditioning will increase muscle perfusion and thereby improve muscle hypertrophy during the subsequent resistance training program.
Onderzoeksopzet
- Pre-endurance training
- Post-endurance training = pre-resistance training
- Post-resistance training
Onderzoeksproduct en/of interventie
- Endurance exercise (if allocated to intervention group)
- Resistance exercise (all participants)
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• Age between 65 and 85 y
• BMI between 18.5 and 30 kg/m2
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• HbA1C level above 6.5%
• Fasted blood glucose level above 6.9 mmol/L and/or 2 hour OGTT glucose level higher than 11.1 mmol/L
• Smoking
• Diabetes
• Cancer
• Cardiovascular disease
• Arthritic conditions
• A history of neuromuscular problems
• Cognitive Impairment
• COPD
• Renal disorder
• Participation in any structured exercise program
• Hypertension, high blood pressure that is above 140/90 mmHg
• Pulmonary disease
• Known allergic reaction to ultrasound contrast-agent
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL7439 |
| NTR-old | NTR7681 |
| Ander register | NL68192.068.1 : 18-060 MEC Maastricht |