RCT to investigate the quality of the of endometrial sample obtained by aspiration when performed before or after the Saline Infusion Sonography (SIS) in postmenopausal women

In this randomised study we will investigate the quality of the endometrial sample obtained by office endometrial sampling when performed before or after the SIS in postmenopausal women. Hypothetically the quality of the sample can be affected by fluid, when performed after the SIS.

The endometrial sample and the SIS will be performed in a outpatient visit. The quality (sufficient for diagnosis) will be determined by a blinded pathologist. The gynaecologist (in training) will evaluate and save the SIS images for a second evaluation.
To evaluate the pain, the gynaecologist(in training) will record VAS scores, during and in between the investigations.



Specific pathological analysis and the second (blinded) evaluation of the SIS images will performed in another session.

We will perform a randomised controlled trial comparing two diagnostic work-ups. One group will first receive SIS and subsequent office endometrial sampling, and the other group will first receive office endometrial sampling and subsequent SIS, both in one session. For both groups we will use a SIS-catheter to perform the SIS and a Pipelle device to perform endometrial sampling.