Sentinel Node And Recurrent Breast cancer

Rationale:

Like in primary breast cancer, prognosis in recurrent breast cancer is correlated with regional lymph node status. Therefore, it seems sensible to perform lymphatic staging in case of an intact axillary lymph node basin, although this has not been described in guidelines yet. Due to surgery and radiotherapy lymph drainage pathways could be altered. These aberrant drainage pathways could be detected with lymphatic mapping and sentinel node biopsy leading to a more thorough staging and possible change in treatment strategy.


Objective:

To propose a regional staging protocol, lymphatic mapping and sentinel node biopsy, for patients with locally recurrent breast cancer in the absence of guidelines for regional staging procedures and to registrate data derived from this study.


Study design:

A prospective, multicenter, national registration study.


Study population:
At least 150 women above 18 years old with locally recurrent breast cancer after earlier BCT or modified radical mastectomy.


Main study parameters/endpoints:
Registration of technical feasibility and validity of lymphatic mapping and sentinel node biopsy in patients with locally recurrent breast cancer as well as registration of lymphatic drainage pathways and sentinel lymph node status. Furthermore, the influence of this staging procedure on therapeutic decisions will be evaluated.

Due to surgery and radiotherapy lymph drainage pathways in recurrent breast cancer could be altered. These aberrant drainage pathways could be detected with lymphatic mapping and sentinel node biopsy leading to a more thorough staging and possible change in treatment strategy.

- Pre-operative inclusion

- Operation

- Post-operative registration: first post-operative consult

Lymfatic Mapping and sentinel lymph node biopsie.