The prevalence of Growth Hormone Deficiency in Autoimmune Thyroid Disease is higher than in the general population
ID
Bron
Verkorte titel
Aandoening
Autoimmune hypothyroidism treated with thyroxine
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Prevalence of growth hormone deficiency in patients with autoimmune hypothyroidism
Achtergrond van het onderzoek
An uncommon cause of growth hormone deficiency is autoimmune (lymphocytic) hypophysitis. Autoimmune hypophysitis is frequently associated with other endocrine or non-endocrine autoimmune diseases.
Data on isolated growth hormone deficiency caused by autoimmune hypophysitis are scarce and inconclusive.
Isolated growth hormone deficiency, as a result of autoimmune hypophysitis, may not be that uncommon, especially in patients with autoimmune thyroid disease.
Autoimmune hypothyroidism is common. Some hypothyroid patients who have been rendered euthyroid by adequate doses of thyroxin, suffer from a reduced quality of life. It is possible that these patients suffer from growth hormone deficiency and that growth hormone replacement would increase their wellbeing. In this study, we want to investigate what the prevalence is of GHD in patients with autoimmune hypothyroidism.
Doel van het onderzoek
The prevalence of Growth Hormone Deficiency in Autoimmune Thyroid Disease is higher than in the general population
Onderzoeksproduct en/of interventie
N/A
Publiek
Department of Endocrinology,
P.O. Box 22660
S.A. Eskes
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5669111
S.A.Eskes@amc.uva.nl
Wetenschappelijk
Department of Endocrinology,
P.O. Box 22660
S.A. Eskes
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5669111
S.A.Eskes@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Autoimmune hypothyroidism
Adequate thyroxine treatment
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. History of hypothalamic or pituitary disease or known growth hormone deficiency
2. Pregnancy
3. Hypothyroidism after treatment for Graves' disease or surgery or I131
4. Major concurrent diseases
5. Use of medications known to interfere with the growth hormone-IGF-1 axis
6. No informed consent
7. Alcohol or drug abuse
Opzet
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL745 |
| NTR-old | NTR755 |
| Ander register | : N/A |
| ISRCTN | ISRCTN57632130 |