ETMI versus Chromoendoscopy in UC

Randomized trial: consecutive patients with longstanding UC will be randomized to undergo surveillance colonoscopy with either ETMI or CE.

CE and AFI are equally effective for the detection of neoplastic lesions in patients undergoing colonoscopic surveillance for UC. Also, the combined use of AFI plus NBI and the use of CE have an equal sensitivity and specificity for the differentiation of non-neoplastic and neoplastic mucosa.

This multicenter trial will include 210 patients with longstanding ulcerative colitis. We are aiming to include the last patient one year after the start of the study (August 2014). It will take approximately three months time to analyze the data.

In this RCT we are comparing ETMI (endoscopic tri modal imaging) with chromoendoscopy in the detection of colonic neoplasia in ulcerative colitis. ETMI is a new endoscopy technique where three types of techniques are incorporated in one device: white light endoscopy, narrow band imaging and autofluorescence imaging. Chromoendoscopy is the technique that nowadays is recommended in IBD (Inflammatory bowel disease) surveillance guidelines. This technique makes use of dye spray to enhance the surface of the colonic mucosa, which is time-consuming. There is data that ETMI is has similar performance as chromoendoscopy, but these two technique have never been compared in a randomised controlled trial.