Image quality on 7T outperforms lower field MRI for patient care and/or clinical research.
ID
Bron
Verkorte titel
Aandoening
sensorineural hearing loss
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
image quality and diagnostic value
Achtergrond van het onderzoek
Over the last decades treatment options for sensorineural hearing loss (SNHL) have greatly improved thanks to new insights into pathophysiology and development of new technologies, e.g. radiosurgery or implantable electronic devices. Due to such advancements there is a growing interest in very detailed evaluation of the inner ear and central auditory pathway in vivo. Such detailed information can be obtained with ultra high field MRI. Yet, the technical complexity accompanying higher magnetic field strengths and the particular anatomic configuration of the temporal bone with many air-bone-fluid interfaces giving cause to artifacts, make 7T imaging of the inner ear and retrocochlear structures demanding. Previously we’ve shown that 7T imaging of the inner ear is feasible, but further improvement and/or extension of the scan protocol is required to meet the needs for therapy planning and therapy monitoring in hearing loss.
This study is a prospective observational study to develop and improve new and existing MR sequences for inner ear imaging at 7T and to investigate the clinical added value of 7T imaging (in comparison to 3T imaging)
Doel van het onderzoek
Image quality on 7T outperforms lower field MRI for patient care and/or clinical research.
Onderzoeksopzet
Participants of this study will undergo medium field MRI (1.5T or 3T) as part of their clinical work-up and an additional 7T MRI
Diagnostic value will be evaluated in comparison to other available imaging studies and/or preoperative findings and/or performance outcome and/or anatomical studies and/or literature values.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- be able and willing of giving informed consent
- age 12-99 years
- clinical indication for MR imaging of the temporal bone and/or auditory pathway
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- contra-indication to MRI exposure, including cardiac pacemaker and implants not approved for ultra-high field MRI (see www.mrsafety.com), pearcings or other metal objects attached to the body that cannot be removed
- claustrophobia
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
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In overige registers
Register | ID |
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NTR-new | NL8247 |
Ander register | METC LUMC : P15.132 |