Objective: The overall aim of this project is to correlate the characteristic changes of the deformation-area loop to the properties of the pressure-volume curve. We hypothesize that the systolic slope of the deformation-area loop relates to the end…
ID
Bron
Verkorte titel
Aandoening
Patients with pulmonary arterial hypertension (PAH)
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
- The relation between the systolic slope of the deformation-area loop and the end-systolic pressure-volume relationship of the pressure volume curve.<br>
- The relation between the slope of the diastolic part of the deformation-area loop during passive filling and the end-diastolic pressure-volume relationship of the pressure volume curve.
Achtergrond van het onderzoek
Recent technical developments allow monitoring of strain and area using echocardiography. Using this information enables the production of an deformation-area loop. In this study we will investigate the relationship between the non-invasive deformation-area loop and the pressure-volume curve, during different loading conditions of the right ventricle
Doel van het onderzoek
Objective: The overall aim of this project is to correlate the characteristic changes of the deformation-area loop to the properties of the pressure-volume curve. We hypothesize that the systolic slope of the deformation-area loop relates to the end-systolic pressure-volume relationship of the pressure volume curve.
Onderzoeksopzet
na
Onderzoeksproduct en/of interventie
To create the pressure-volume changes we will use a balloon-catheter to partially obstruct the venous return in the Vena Cava inferior.
Publiek
Hugo Hulshof
Nijmegen 6525 EX
The Netherlands
telephone +31 (024) 3614209
Hugo.G.Hulshof@radboudumc.nl
Wetenschappelijk
Hugo Hulshof
Nijmegen 6525 EX
The Netherlands
telephone +31 (024) 3614209
Hugo.G.Hulshof@radboudumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- strong suspicion of PAH, WHO group 1, confirmed during right hearth catheterization.
- Over 18 years of age
- voluntary
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- cardiovascular diseases, other than PAH
- diabetes mellitus
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL6789 |
| NTR-old | NTR6974 |
| Ander register | CMO regio Arnhem-Nijmegen : 2017-3460 |