Loss of amino acids during hemodialysis

‘Chronic hemodialysis patients show declined muscle function, exercise performance and quality of life after hemodialysis treatment is necessary. The cause of this decline is suggested to be multifactorial. One of the most important catabolic stimuli present in chronic hemodialysis patients might be loss of nutrients in the dialysate. Amongst these nutrients, amino acids form the most important macronutrients, as these are essential for muscle maintenance. To date, studies which assessed the amount of amino acid loss during hemodialysis did so in fasted patients. However, this might not represent the amino acid loss during routine hemodialysis, during which most patients are allowed to eat and/or drink. Therefore, this study will assess the amino acid loss in chronic hemodialysis patients consuming their habitual diet.’

We hypothesize that the amino acid loss in the dialysate during a routine HD session in the MUMC+ will be between 8-12 g/session, resulting in a significant decline in plasma free amino acid concentration.

Pre (t=0) and post (t=180 - 300) hemodialysis

Every 30 minutes of the hemodialysis procedure (t=30, t=60, t=90, t=120, t=150, t=180, t=210, t=240, t=270).

N/A