The Staphylococcus aureus bacteria with insensitivity for methicillin antibiotics: a search for new risk factors and renewel of the guidelines / De Staphylococcus aureus bacterie met ongevoeligheid voor meticilline antibiotica: Een zoektocht naar nieuwe risicofactoren en vernieuwing van de richtlijnen.

The Erasmus MC, department of Medical Microbiology
and Infectious diseases has teamed up with the Center of Infectious
Disease Control of the RIVM for a new research project. The research
project is about MRSA of Unknown Origin: MUO – Risk Assessment and
Adjustment of Risk Classification. The research team, under guidance of
M.C.Vos (ErasmusMC) and N. van de Sande (CIb/EPI), will try to sort out
what causes an alarming rise of MRSA-prevalence outside the healthcare
facilities, presumably due to unknown sources. This rise consists out of
carriers without known risk factors, who fall outside our described risk
categories in the WIP guideline. This could be a threat to our
successful Search&Destroy policy.

The aim of the research is to find an explanation for the presence of
MUO in people without known risk factors for MRSA carriage. If a reason
is found, this will result in adaptation of the current guidelines. This
study is financed by ZonMW (government).

The current rise of CA-MRSA in the Netherlands is due to them all being MRSA of Unknown Origin (MUO). We do not know the risk factors yet of these. If we do, the CA-MRSA will drop.

No interim analysis needed/planned.

None.