We hypothesize that prenatal exposure to AMH is responsible for the development of MRKH in the female. The anogenital distance (AGD) and the ratio between the length of the 2nd and 4th digit (2D:4D ratio) have been described as biomarkers of…
ID
Bron
Verkorte titel
Aandoening
PCOS, endometriosis and MRK syndrome
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The primary outcome is the difference in AGDac in all 4 groups.
Achtergrond van het onderzoek
Mayer Rokitansky Küster Hauser (MRKH) syndrome is a congenital disorder, characterized by aplasia of the uterus and the upper two thirds of the vagina. The aetiology is unknown. We hypothesize that prenatal exposure to AMH is responsible for the development of MRKH in the female. The anogenital distance (AGD) and the ratio between the length of the 2nd and 4th digit (2D:4D ratio) have been described as biomarkers of prenatal androgen exposure. In women with polycystic ovary syndrome (PCOS) longer AGD is reported, suggesting that the origin of PCOS is possibly due to prenatal exposure to androgens. In women with severe endometriosis a decreased AGD has been reported, possibly due to oestrogenic intrauterine influence.
We will perform measurements by digital calliper of the AGD and 2D:4D ratio in women with MRK, PCOS, endometriosis and a control group.
Doel van het onderzoek
We hypothesize that prenatal exposure to AMH is responsible for the development of MRKH in the female. The anogenital distance (AGD) and the ratio between the length of the 2nd and 4th digit (2D:4D ratio) have been described as biomarkers of prenatal androgen exposure. In women with polycystic ovary syndrome (PCOS) longer AGD is reported, suggesting that the origin of PCOS is possibly due to prenatal exposure to androgens. In women with severe endometriosis a decreased AGD has been reported, possibly due to oestrogenic intrauterine influence.
Onderzoeksopzet
Only one study visit for completing questionnaire and measurements.
Onderzoeksproduct en/of interventie
- measurement of AGD by digital calliper (AGDac, anterior clitoral surface to the centre of the anus; AGDaf, from the posterior fourchette to the centre of the anus)
- measurement of 2D:4D ratio by digital calliper
- measurement of 2D:4D ratio by computer-assisted analysis
Publiek
Henrike Peters
Postbus 7057
Amsterdam 1007 MB
The Netherlands
0204440561
h.peters@vumc.nl
Wetenschappelijk
Henrike Peters
Postbus 7057
Amsterdam 1007 MB
The Netherlands
0204440561
h.peters@vumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
4 groups:
MRK syndrome:
- Diagnosed with MRK
- age >18 years
PCOS:
- Diagnosed with PCOS
- age >18 years
endometriosis:
- Diagnosed with endometriosis
- age >18 years
Control:
- Age ¡Ý 18 years
- Regular, ovulatory cycle
- ICSI treatment for male infertility
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
MRK syndrome:
no exlusion criteria
PCOS group:
- vaginal delivery in the medical history
- diagnosed with endometriosis
Endometriosis group:
- vaginal delivery in the medical history
- diagnosed with PCOS
Control group:
- diagnosed with PCOS/endometriosis
- ICSI treatment after a total fertilization failure in IVF cycle
- vaginal delivery in the medical history
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL7276 |
| NTR-old | NTR7492 |
| CCMO | NL64437.029.18 |
| OMON | NL-OMON48729 |