1. Both paroxetine and cognitive behavioural therapy (CBT) are effective in the treatment of late-life panic disorder; 2. Differences in efficacy between paroxetine and CBT are small.
ID
Bron
Verkorte titel
Aandoening
1. Panic disorder;
2. aged;
3. drug therapy;
4. cognitive therapy;
5. paroxetine.
(NLD: Paniekstoornis, ouderen, farmacotherapie, cognitieve gedragstherapie, paroxetine).
Ondersteuning
2. GGz Nijmegen, Outpatient Department for Anxiety Disorders, Nijmegen
PO Box 7049, 6503 GM Nijmegen, the Netherlands.
Glaxo SmithKline BV, PO Box 780, 3700 AT Zeist, the Netherlands.
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Self-report instruments for anxiety cogntions and phobic avoidance: scores on the Dutch adaptations of the Agoraphobic Cognitions Questionnaire (ACQ) and the Mobility Inventory avoidance scale (MI).
Achtergrond van het onderzoek
N/A
Doel van het onderzoek
1. Both paroxetine and cognitive behavioural therapy (CBT) are effective in the treatment of late-life panic disorder;
2. Differences in efficacy between paroxetine and CBT are small.
Onderzoeksopzet
Assessments were completed at:
1. Week 0;
2. Week 8;
3. Week 14;
4. Week 26.
Onderzoeksproduct en/of interventie
1. Treatment with paroxetine 20 mg 1dd2 during 14 weeks;
2. Cognitive behavioural therapy according to a treatment manual for panic disorder during 14 weekly sessions;
3. A waiting-list control condition of 14 weeks.
For both active treatments, paroxetine and CBT, follow-up period is 12 weeks.
Publiek
PO Box 7049,
G.J. Hendriks
Nijmegen 6503 GM
The Netherlands
+31-24-3837820
ghendriks@ggznijmegen.nl
Wetenschappelijk
PO Box 7049,
G.J. Hendriks
Nijmegen 6503 GM
The Netherlands
+31-24-3837820
ghendriks@ggznijmegen.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Panic disorder with/without agoraphobia (DSM-IV-criteria);
2. >60 years.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. The presence of severe psychiatric disorders (e.g. psychosis, major depression, bipolar disorder);
2. A severe somatic condition which would hinder appropriate application of CBT (e.g. severe cardiovascular disease);
3. A contraindication for prescribing paroxetine (e.g. co-occurring use of anti-coagulantia);
4. Current use of an antidepressant in an adequate dose;
5. Current and adequate psychological treatment;
6. Abuse or dependency of alcohol or psychoactive substances;
7. Dementia and a score of 23 or less on the Mini-Mental State Examination.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1110 |
| NTR-old | NTR1144 |
| Ander register | CCMO-Arnhem/Nijmegen : 9803-0063. |
| ISRCTN | ISRCTN wordt niet aangevraagd/retrospectief |