Doxycycline will ameliorate the vascular condition and inflammatory status in patients with mild to moderate atherosclerotic disease
ID
Bron
Verkorte titel
Aandoening
atherosclerosis, peripheral arterial disease, inflammation, Doxycycline
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Endothelial function
Achtergrond van het onderzoek
Patients with mild to moderate peripheral arterial disease were treated with doxycycline 100mg daily or placebo.
Reduction in vascular inflammation was assessed by measuring vascular endothelial function and peripheral plasma markers of inflammation.
Doel van het onderzoek
Doxycycline will ameliorate the vascular condition and inflammatory status in patients with mild to moderate atherosclerotic disease
Onderzoeksopzet
t=0, follow up after 30, 60, 90 and 120 days
Onderzoeksproduct en/of interventie
Patients were (if necessary) pre-treated with or switched to simvastatin 40 mg daily at least four weeks prior to trial start.
Patients were treated with 100 mg doxycycline for four weeks
Publiek
Dpt. of Vascular Surgery.<br>
PO-box 9600
Jan H. Lindeman
Leiden 2300 RC
The Netherlands
Lindeman@lumc.nl
Wetenschappelijk
Dpt. of Vascular Surgery.<br>
PO-box 9600
Jan H. Lindeman
Leiden 2300 RC
The Netherlands
Lindeman@lumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Patients suffering from mild to moderate stable peripheral arterial disease who do not require carotis or femoral endarteriectomy (Fontaine IIa)
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Known hypersensitivity for tetracycline derivates
2. Patients treated with antibiotics in last 3 months for other diseases then lower urinary tract infections
3. Patients treated with immunosuppressive agents (including steroids)
4. Patients treated with fibrates
5. Patients with Diabetes Mellitus regulated with drug therapy
6. Signs of kidney or liver failure
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1331 |
| NTR-old | NTR1389 |
| Ander register | METC LUMC : P05.189 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |