Patient with a low baseline HSP level are more likely to have atrial electropathology and to develop postprocedural atrial fibrillation.
ID
Bron
Verkorte titel
Aandoening
Atrial Fibrillation
Epicardial Mapping
Heat Shock Protein
Cardiac Surgery
Pulmonary Vein Isolation
Electrical Cardioversion
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Main endpoint of the study is development or recurrence of AF, or completion of five year follow up period. We will test the correlation between HSP levels and development or recurrence of AF, and the correlation between degree of electropathology and development/recurrence of AF.
Doel van het onderzoek
Patient with a low baseline HSP level are more likely to have atrial electropathology and to develop postprocedural atrial fibrillation.
Onderzoeksopzet
T = 0: procedure
Follow up:
T = 1: 6 mo
T = 2: 12 mo
T = 3: 24 mo
T = 4: 36 mo
T = 5: 48 mo
T = 6: 60 mo
Onderzoeksproduct en/of interventie
In patients undergoing cardiac surgery:
- Epicardial mapping
- Biopsie atrial appendage
In patients undergoing pulmonary vein isolation:
- Endovascular mapping
In all patients: bloodsamples for HSP determination
Publiek
N.M.S. Groot, de
Erasmus MC, afdeling Cardiologie, Kamer BA-579
Rotterdam 3015 CE
The Netherlands
+31 (0)10 7034479
n.m.s.degroot@erasmusmc.nl
Wetenschappelijk
N.M.S. Groot, de
Erasmus MC, afdeling Cardiologie, Kamer BA-579
Rotterdam 3015 CE
The Netherlands
+31 (0)10 7034479
n.m.s.degroot@erasmusmc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Adult (>18 yr) patients undergoing elective cardiac surgery, pulmonary vein isolation or electric cardioversion
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Paced Atrial Rhythms
Hemodynamic Instability
Presence of Assist Devices
Usage of Inotropic Agents
Emergency Cardiac Surgery
Redo Cardiac Surgery
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4524 |
| NTR-old | NTR4658 |
| CCMO | NL49785.078.14 |
| OMON | NL-OMON53108 |