The microcirculatory profile is altered in infants with NEC.
ID
Bron
Verkorte titel
Aandoening
Necrotizing enterocolitis (NEC). In Dutch: necrotiserende enterocolitis.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
To determine the microcirculatory profile in infants with persistent feeding intolerance or suspected NEC. We would like to determine whether NEC is associated with a regional decreased microcirculation.
Achtergrond van het onderzoek
The microcirculation might play an important role in the pathogenesis of necrotizing enterocolitis. We would like to determine the microcirculatory profile using different techniques (SDF, NIRS and Doppler) and perform basic scientific research to evaluate the mesenteric vascular response.
Doel van het onderzoek
The microcirculatory profile is altered in infants with NEC.
Onderzoeksopzet
Neonates from group 1 and 2 will be followed for 7 consecutive days.
In case of an operative procedure for neonates in group 1, intra-operative measurements will be performed and for 3 days following surgery. Infants from group 3 will be used as control patients for the intra-operative measurements.
Onderzoeksproduct en/of interventie
This is an observational study. The following techniques will be used to monitor the microcirculatory profile in the groups described in inclusion criteria:
1. Sidestream darkfield imaging (SDF): non-invasive assessment microcirculation;
2. Near infrared spectroscopy (NIRS): non-invasive measurement of tissue oxygenation;
3. Doppler: flow velocity of superior mesenteric artery.
Publiek
A.E.C.J.M. Struijs
Dr. Molewaterplein 60, Sk-1324
Rotterdam 3015 GJ
The Netherlands
+31 (0)10-7036889
a.e.c.j.m.struijs@erasmusmc.nl
Wetenschappelijk
A.E.C.J.M. Struijs
Dr. Molewaterplein 60, Sk-1324
Rotterdam 3015 GJ
The Netherlands
+31 (0)10-7036889
a.e.c.j.m.struijs@erasmusmc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Group 1: All neonates suspected of NEC or severe feeding intolerance;
2. Group 2: Control patients for group 1, matched for gender and age;
3. Group 3: neonates with congenital gastrointestinal pathology, ie atresia, gastroschisis, omphalocele.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Severe cardiac and respiratory anomalies.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1840 |
| NTR-old | NTR1951 |
| Ander register | METC Erasmus Medical Center : MEC-2009-198 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |