There is increasing evidence that women with hypertension or preeclampsia during pregnancy are at increased of cardiovascular diseases later in life compared to women with normotensive pregnancies. As suggested by previous studies, placenta…
ID
Bron
Verkorte titel
Aandoening
Recurrent miscarriages
cardiovascular disease
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. Blood pressure;<br>
2. Body mass index;<br>
3. Venous blood sampled: Glucose, HbA1c, insulin, total cholesterol, HDL cholesterol, triglycerides and HsCRP;<br>
4. Urine: Microalbumin.
Achtergrond van het onderzoek
Recurrent miscarriages is commonly defined as three or more consecutive miscarriages prior to the 20th week. It is a common problem affecting 1 to 2% of all fertile couples and is a highly heterogeneous condition. An underlying cause may be identified in about 25-50% of cases.
There is increasing evidence that women with hypertension or preeclampsia during pregnancy are at increased of cardiovascular diseases later in life compared to women with normotensive pregnancies. As suggested by previous studies, placenta insufficiency syndrome maybe a first sign of cardiovascular disease, which could also be true for recurrent miscarriages.
Identifying women with risk factors for cardiovascular diseases as early as possible makes it possible for them to benefit from preventive interventions.
Doel van het onderzoek
There is increasing evidence that women with hypertension or preeclampsia during pregnancy are at increased of cardiovascular diseases later in life compared to women with normotensive pregnancies. As suggested by previous studies, placenta insufficiency syndrome maybe a first sign of cardiovascular disease, which could also be true for recurrent miscarriages.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
Assessment of classic cardiovascular risk factors will be performed for women with recurrent miscarriages vs women with an uncomplicated pregnancy in history.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Women who visited the recurrent miscarriages clinic since 2000. The time interval between their first miscarriage and the time of inclusion has to be at least 2 years.
The control group will be derived from the Hyras study. The controls were required to have one or more uncomplicated pregnancy (ies) in their history.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Lactating and pregnant (within the last 3 months) women.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL3256 |
| NTR-old | NTR3408 |
| Ander register | ABR : 40524 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |