A placebo controlled study on the effect of oxandrolone in combination with authentic biosynthetic human growth hormone and low-dose oestrogens on growth and metabolic parameters in girls with Turner's syndrome.

Double-blind RCT on the effect of oxandrolone in two dosages (vs placebo) on long-term effects on growth, voice characteristics, psychosexual dedvelopment and carbohydrate metabolism.

Adding oxandrolone to the standard treatment of GH (in adolescence combined with oestrogens) increases growth velocity and final height. Adding oxandrolone does not lead to untoward side effects, e.g. on voice characteristics.

Three arm study:
1) GH alone (plus oestrogens in adolescence);
2) idem plus low-dose oxandrolone (0.03 mg/kg body weight/day;
3) idem plus moderate-dose oxandrolone (0.06 mg/kg/day.