Seventy percent of patients with schizophrenia and other psychotic disorders has paranoid delusions. Paranoid delusions are associated with great distress, hospital admission and social isolation. Cognitive behavioral therapy (CBT) is the main…
ID
Bron
Verkorte titel
Aandoening
Virtual Reality, Schizophrenia, Psychosis, Cognitive Behavioral Therapy, Exposure Therapy
Virtual Reality, Schizofrenie, Psychose, Cognitieve Gedragstherapie, Exposure Therapie
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Primary outcome is level of paranoid ideations in daily life social situations, measured with ecological momentary assessments (EMA). EMA is a structured diary method in which individuals are asked in normal daily life to report their momentary thoughts, feelings and symptoms, as well as the (appraisal of the) social context.
Achtergrond van het onderzoek
Seventy percent of patients with schizophrenia and other psychotic disorders has paranoid delusions. Paranoid delusions are associated with great distress, hospital admission and social isolation.Cognitive behavioral therapy (CBT) is the main psychological treatment, but the median effect size is only small to medium. Virtual reality (VR) has a great potential to improve psychological treatment of paranoid delusions. Preliminary studies suggest that VR based CBT (VRcbt) for paranoid delusions may be more (cost-)effective than standard CBT. The aim of this project is to test this hypothesis.
In a multicenter Randomized Controlled Trial (n=106), this study will investigate if VRcbt is more (cost-) effective than standard CBT for treatment of paranoid delusions and improving daily life social functioning of patients with schizophrenia and related psychotic disorders. In both conditions participants will receive maximum 16 sessions of treatment.
Doel van het onderzoek
Seventy percent of patients with schizophrenia and other psychotic disorders has paranoid delusions. Paranoid delusions are associated with great distress, hospital admission and social isolation. Cognitive behavioral therapy (CBT) is the main psychological treatment, but the median effect size is only small to medium. Virtual reality (VR) has a great potential to improve psychological treatment of paranoid delusions. Preliminary studies suggest that VR based CBT (VRcbt) for paranoid delusions may be more (cost-)effective than standard CBT. The aim of this project is to test this hypothesis.
Onderzoeksopzet
All measures will be administered at baseline (T0), after treatment (T3) and 6 months after treatment (T6), by raters who are blind for the treatment allocation of the participants.
Onderzoeksproduct en/of interventie
VRcbt consists of maximum 16 sessions in virtual social situations that trigger paranoid ideations and distress, delivered in an 8-12 week time frame. Standard CBT also consists of maximum 16 sessions, aiming at reappraisal of the meaning of paranoid beliefs to reduce distress and improve coping in daily life, including the use of exposure and behavioral experiments.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- DSM-5 diagnosis of schizophrenia spectrum or other psychotic disorder.
- At least a moderate level of paranoid ideations (GPTS >40).
- Age 18-65
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- IQ under 70
- Insufficient command of Dutch language
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Toelichting
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL7758 |
| Ander register | Medisch Ethische Toetsingscommissie van het Universitair Medisch Centrum Groningen : METc 2018.425; ABR NL66850.042.18; UMCG 201800564 |