1. Organ-specific protein synthesis rates will be higher than muscle protein synthesis rates. 2. Tumor-specific protein synthesis rates will be higher than organ-specific protein synthesis rates.
ID
Bron
Verkorte titel
Aandoening
Protein synthesis in muscle tissue has been well studied in different conditions. Protein turnover in other organs however, has not yet been investigated using contemporary research methods. The goal of this study is to determine fractional protein synthesis rates in different organ tissues during surgery. Furthermore, protein synthesis rates in several tumors will be measured.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Fractional synthetic rate (FSR) and enrichment (MPE) in vastus lateralis and organ tissue.
Achtergrond van het onderzoek
-
Doel van het onderzoek
1. Organ-specific protein synthesis rates will be higher than muscle protein synthesis rates.
2. Tumor-specific protein synthesis rates will be higher than organ-specific protein synthesis rates.
Onderzoeksopzet
Several Blood draws before and during surgery. Tissue sample during surgery at the moment tissue is removed.
Onderzoeksproduct en/of interventie
none
Publiek
Joey Smeets
Maastricht 6229 ER
The Netherlands
+31 43 388 2215
joey.smeets@maastrichtuniversity.nl
Wetenschappelijk
Joey Smeets
Maastricht 6229 ER
The Netherlands
+31 43 388 2215
joey.smeets@maastrichtuniversity.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Age 18 to 85 years
- Compos mentis
- Surgical intervention for oesophagus carcinoma, colon carcinoma, aortic valve insufficiency, lung carcinoma, renal rell carcinoma, epilepsy, hip fracture or osteo-arthritis of the knee
- Written informed consent
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Co-morbidities and neuromuscular disorders of the lower limbs severely interacting with mobility with limited or no opportunity for improvement (e.g. cerebral palsy);
- Peripheral arterial disease Fontaine III or IV;
- Chronic obstructive pulmonary disease (COPD) GOLD III or IV;
- Use of systemic steroids in the past four weeks, other than indicated for the specific type of surgery;
- Use anti-inflammatory biologicals (e.g. TNF-alfa blockers) in the past four weeks;
- Phenylketonuria (PKU);
- Surgical intervention in the past four weeks;
- Insulin dependent diabetes mellitus;
- Total parenteral nutrition at day of surgery;
- Pregnancy;
- Neoadjuvant chemo- or radiotherapy in the past four weeks;
- Organ-specific exclusion criteria (see below).
Organ specific exclusion criteria:
Heart:
- Medical history of ischemic heart disease
- Heart failure
Kidney:
- Diabetes Mellitus
- GFR < 20 ml/min/1.73 m2
Bone:
- Life expectancy <6 months
- Time to surgery >48 hours
Knee:
- Use of injected corticosteroids in the replaced knee the past 3 months
- Use of bisphosphonates in the past 3 months
- Rheumatoid arthritis or other inflammatory joint diseases
- Knee surgery within the last 3 months
- Osteoarthritis of the knee secondary to septic arthritis, osteonecrosis, fracture, OD and tumor
- Collagen disorders, e.g. Marfan and Ehler-Danlos
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4876 |
| NTR-old | NTR5147 |
| CCMO | NL51743.096.14 |
| OMON | NL-OMON47497 |