SARS-CoV-2 is present in the cerebrospinal fluid of COVID-19 patients with acute respiratory failure
ID
Bron
Aandoening
COVID-19
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
SARS-CoV-2 RT-PCR of cerebrospinal fluid
Achtergrond van het onderzoek
Rationale: Acute respiratory failure in COVID-19 may be caused by neuroinvasion of SARS-CoV-2.
Objective: To investigate the prevalence of SARS-CoV-2 presence in the cerebrospinal fluid of patients with a proven SARS-CoV-2 infection and acute respiratory failure.
Study design: Pilot study
Study population: Adult (>18 years of age) COVID-19 patients admitted to the Zuyderland hospital in the Netherlands.
Intervention (if applicable): -
Main study parameters/endpoints: RT-PCR of SARS-CoV2 in the cerebrospinal fluid.
Nature and extent of the burden and risks associated with participation, benefit and group relatedness: All patients will be exposed to the complications and discomfort associated with diagnostic lumbar puncture, which is considered a low-risk procedure. As patients will be sedated during the procedure, they will not experience periprocedural discomfort. The study is considered group-related as uncovering the pathophysiology of acute respiratory distress in COVID-19 patients may be a starting point for research aimed at improving the prognosis of COVID-19 patients.
Doel van het onderzoek
SARS-CoV-2 is present in the cerebrospinal fluid of COVID-19 patients with acute respiratory failure
Onderzoeksopzet
Follow-up after 8 weeks
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- At least 18 years of age
- Requires mechanical ventilation
- Proven SARS-CoV-2 infection
- Lumbar puncture possible within 48 hours of ICU admission
- Informed consent provided by either patient or legal representative
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Contraindication for lumbar puncture
- Proven or suspected cerebrospinal fluid leak or other blood-brain barrier defects
- Any condition known to alter cerebrospinal fluid biochemistry
- Known or suspected cause for respiratory failure, other than COVID-19
- Any disease known for decreasing pulmonary capacity or compliance
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL8526 |
| Ander register | METC Z : Z2020090 |