Non-invasive ventilation reduces the inflammatory response to exercise.
ID
Bron
Verkorte titel
Aandoening
Chronic obstructive pulmonary disease
Chronisch obstructief longlijden, chronische bronchitis, longemfyseem
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Systemic inflammatory response.
Achtergrond van het onderzoek
The effect of non-invasive ventilation during exercise on systemic inflammatory responses will be investigated in a double blind randomized placebo controlled (sham ventilation) cross-over design. During the first visit patients will cycle as long as possible, but maximally 20 minutes and during the second visit they will be asked to cycle exactly as long as during the first visit (isotime). Blood will be obtained at rest, at the end of the activity and 30 minutes afterwards to investigate markers of systemic inflammation.
Doel van het onderzoek
Non-invasive ventilation reduces the inflammatory response to exercise.
Onderzoeksopzet
1. Rest;
2. After exercise;
3. 30 minutes after exercise.
Onderzoeksproduct en/of interventie
Non-invasive ventilation & sham ventilation.
Publiek
Radboud University Nijmegen Medical Centre
PO Box 9101
JDC Hannink
Department of Pulmonary Diseases
Radboud University Nijmegen Medical Centre
PO Box 9101
Nijmegen 6500 HB
The Netherlands
+31 (0)24-6859580
J.Hannink@LONG.umcn.nl
Wetenschappelijk
Radboud University Nijmegen Medical Centre
PO Box 9101
JDC Hannink
Department of Pulmonary Diseases
Radboud University Nijmegen Medical Centre
PO Box 9101
Nijmegen 6500 HB
The Netherlands
+31 (0)24-6859580
J.Hannink@LONG.umcn.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
COPD patients.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Long term oxygen therapy;
2. Respiratory insufficiency;
3. Asthma;
4. Exercise limiting disorders;
5. Exacerbation in last 6 weeks;
6. Smoking;
7. Oral corticosteroids;
8. Chronic inflammatory disorders.
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1877 |
| NTR-old | NTR1991 |
| Ander register | METC Radboud University Nijmegen : 2008/125 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |