There are clues that the ThinPrep method has a higher detection of cervical epithelial abnormalities. A cost-effectiveness study is needed to determine whether implementation in the Dutch national cervical screening program is useful.
ID
Bron
Verkorte titel
Aandoening
1. Cervical cancer screening;
2. liquid based cytology;
3. ThinPrep;
4. conventional cytology.
Ondersteuning
European Cancer Network and the Dutch Ministery of Health, through the National Institute for Public Health and Environment.
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. Cost effectiveness in terms of incremental cost per additional abnormal case detected;<br>
2. Costs per invasive cancer prevented and life years gained.
Achtergrond van het onderzoek
In this trial, cost-effectiveness and accuracy of the liquid-based ThinPrep cytology is compared with conventional cytology. The two-centre, cluster randomized controlled trial is performed within the national cervical screening program and includes 90.000 participants. The results of this trial will be helpful to determine whether implementation in the national cervical screeningprogram will be useful.
Doel van het onderzoek
There are clues that the ThinPrep method has a higher detection of cervical epithelial abnormalities. A cost-effectiveness study is needed to determine whether implementation in the Dutch national cervical screening program is useful.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
Comparing performance of ThinPrep with conventional cytology.
Publiek
Dept of Pathology
PO Box 9101,
huispost 824
J. Bulten
Nijmegen 6500 HB
The Netherlands
+31 (0)24-3614323
h.bulten@pathol.umcn.nl
Wetenschappelijk
Dept of Pathology
PO Box 9101,
huispost 824
J. Bulten
Nijmegen 6500 HB
The Netherlands
+31 (0)24-3614323
h.bulten@pathol.umcn.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Women, participating in the national cervical screening program, recruited from family practices who were randomised to experimental arm (ThinPrep) or control arm (conventional cytology).
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
N/A
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1003 |
| NTR-old | NTR1032 |
| Ander register | : EU/CVZ nummer |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |