We hypothesize that cardiovascular disease and impaired quality of life are frequent long-term complications in AAV and often underdiagnosed.
ID
Bron
Verkorte titel
Aandoening
ANCA-associated vasculitis, granulomatosis with polyangiits (GPA), microscopic polyangiitis (MPA), Cardiovascular disease, quality of life, depression.
Ondersteuning
Roche Nederland B.V.
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The prevalence of chronic damage in ANCA-associated vasculitis, defined as:<br>
- Prevalence of cardiovascular disease <br>
- Impaired quality of life <br>
- Depression<br>
Doel van het onderzoek
We hypothesize that cardiovascular disease and impaired quality of life are frequent long-term complications in AAV and often underdiagnosed.
Onderzoeksopzet
One visit will be scheduled for all patients in which damage scores and disease activity scores will be calculated. Furthermore during this visit skin autofluoresence will be measured in all patients. Patients will fill out questionnaires on quality of life and depression in advance of the scheduled appointment.
Onderzoeksproduct en/of interventie
No intervention planned. Data will be collected from routine patient visits, questionnaires and non-invasive measurements.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
In order to participate in this study, a subject must meet all of the following criteria:
• Diagnosis GPA or MPA in accordance with the Chapel Hill Consensus Conference guidelines
• PR3 and/or MPO ANCA positive between 2005 and 2016
• Age ≥ 18 years
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Secondary vasculitis due to rheumatoid arthritis, systemic lupus erythematosus, Sjögren’s syndrome, connective tissue disease
- Drug induced vasculitis
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5883 |
| NTR-old | NTR6056 |
| Ander register | METC NH : M016-025 |