Energy restriction by bariatric surgery in obese women increases bone marrow fat and decreases bone mass.
ID
Bron
Verkorte titel
Aandoening
Obesity
Surgery induced weight loss
Osteoporosis
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
* Vertebral bone marrow fat fraction measured by QSCI<br>
* Vertebral bone mineral density measured by QCT
Achtergrond van het onderzoek
Bone marrow fat and bone mineral density are inversely correlated. Greater bone marrow fat is also associated with fractures. Bone marrow fat is regulated differently from visceral and subcutaneous fat. In rodents, caloric restriction results in high bone marrow fat. However, little studies have been published that examined the effects of weight loss on bone marrow fat in humans.
Doel van het onderzoek
Energy restriction by bariatric surgery in obese women increases bone marrow fat and decreases bone mass.
Onderzoeksopzet
* 3 months and 2 weeks pre-operative
* 3 and 12 months post-operative
Onderzoeksproduct en/of interventie
Roux-en-Y gastric bypass
Publiek
P.H.L.T. Bisschop
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666071
p.h.bisschop@amc.uva.nl
Wetenschappelijk
P.H.L.T. Bisschop
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666071
p.h.bisschop@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
* Female sex
* Age: 18-55 years50 years and older
* Postmenopausal
* Scheduled for Roux-en-Y gastric bypass
* Able to fit on MRI table
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
* Contraindications to MRI scanning
* Use of bone-modifying or adipose tissue-modifying drugs
* Bone / bone marrow diseases
* Diseases or medication known to have an effect on bone marrow fat
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4951 |
| NTR-old | NTR5056 |
| CCMO | NL51696.018.14 |
| OMON | NL-OMON43737 |