Hyperplastic polyposis syndrome (HPS) is characterized by the presence of multiple colorectal serrated polyps and co-existent conventional adenomas and is associated with an increased colorectal cancer (CRC) risk 1-9. Considering the presumed…
ID
Bron
Verkorte titel
Aandoening
Hyperplastic
Polyposis
Syndrome
Narrow Band Imaging
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Polyp miss-rates of NBI vs. HRE.
Achtergrond van het onderzoek
N/A
Doel van het onderzoek
Hyperplastic polyposis syndrome (HPS) is characterized by the presence of multiple colorectal serrated polyps and co-existent conventional adenomas and is associated with an increased colorectal cancer (CRC) risk 1-9. Considering the presumed increased risk of malignant progression of polyps in HPS, detection and removal of polyps seems necessary to prevent CRC development in these patients. However, serrated polyps, which are the overall majority in HPS, are generally small in size, flat in shape and unremarkable in colour. These features are associated with polyp miss-rates of up to 26% using standard colonoscopy. Narrow-band imaging (NBI) may improve the detection and differentiation of these polyps.
Onderzoeksopzet
1. Inclusion: october 2010- end 2011;
2. Data analysis: december 2011.
Onderzoeksproduct en/of interventie
All patients will undergo tandem colonoscopy with HRE and NBI, in randomized order with removal of all detected polyps ≥3 mm after characterization for Kudo pit pattern and vascular pattern intensity (VPI).
Publiek
Y. Hazewinkel
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5662806
y.hazewinkel@amc.uva.nl
Wetenschappelijk
Y. Hazewinkel
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5662806
y.hazewinkel@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
All HPS patients, defined as having:
1. ≥5 HPs/SSAs proximal to the sigmoid colon of which 2 are greater than 10mm in diameter or;
2. ≥20 HPs/SSAs spread throughout the colon.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Patients carrying a germline mutation in the MutYH (biallelic) or APC gene and individuals who have undergone a total colonic resection;
2. History of inflammatory bowel disease;
3. Severe coagulopathy;
4. Age less than 18 years and;
5. Insufficient bowel preparation (<90% of colonic mucosa visible).
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL2390 |
| NTR-old | NTR2497 |
| Ander register | METC AMC : 10/160 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |