SCS and/or DRGS alleviates histamine induced itch.
ID
Bron
Verkorte titel
Aandoening
Not applicable
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
VAS for itch.
Achtergrond van het onderzoek
Electrical neuromodulation therapies such as transcutaneous electrical nerve stimulation (TENS), spinal cord stimulation (SCS) and dorsal root ganglion stimulation (DRGS) have earned their place in the treatment of neuropathic pain and are commonly used as a last resort treatment for neuropathic pain. Though it is known that pain and itch are neurologically related phenomena, electrical neuromodulation is far less used in the treatment of itch. Nonetheless, there is evidence that modes of electrical neuromodulation such as TENS are useful in the treatment of itch. We therefore aim to determine whether SCS and/or DRGS can influence the perception of experimentally induced itch.
Doel van het onderzoek
SCS and/or DRGS alleviates histamine induced itch.
Onderzoeksopzet
Baseline, 15 minutes after histamine application and 1, 5, 10, 15, and 30 minutes after switching on SCS or DRGS.
Onderzoeksproduct en/of interventie
Percutaneous administration of a drop of histamine solution to an area innervated by the SCS or DRGS and simultaneous administration of a drop of histamine solution to an area not innervated by the SCS or DRGS.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Good effect of SCS or DRGS; the area innervated by the SCS or DRGS must extend to a healthy, pain free area of skin; participants must not have objections against switching off his or her SCS or DRGS for up to one hour; age >= 18 years; no ongoing itch perception.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Generalized skin disorder; systemic disease associated with pruritus; complex regional pain syndrome; allergy or hypersensitivity; contra-indications for histamine administration; use of opioids; use of drugs that might potentially prevent the development of a flare.
Opzet
Deelname
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Toelichting
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL8591 |
| Ander register | METC Erasmus MC : MEC-2020-0241 |