A restrictive fluid regimen is beneficial for postoperative recovey after abdominal surgery, as to hospital stay and postoperative complications.
ID
Bron
Verkorte titel
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Length of hospital stay.
Achtergrond van het onderzoek
Background:
Intravenous fluid administration after abdominal surgery is an essential, but variable part of postoperative care. The optimum suppletion volume after abdominal surgery is unknown. In colorectal surgery a restrictive fluid regime was found to reduce complications. We investigated the benefits of a restrictive postoperative intravenous fluid management in patients undergoing elective abdominal surgery.
Methods:
In a triple-blinded trial we randomly allocated patients undergoing elective abdominal surgery to a restrictive postoperative regime of 1,5 litre intravenous fluid/24h vs. 2,5 litre/24h, which was standard hospital practice. Primary outcome measure was length of hospital stay (LOS), secondary measures were postoperative complications and time to restoration of gastric functions and normal diet.
Doel van het onderzoek
A restrictive fluid regimen is beneficial for postoperative recovey after abdominal surgery, as to hospital stay and postoperative complications.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
1,5 litre intravenous fluid/24h vs. 2,5 litre/24h.
Publiek
P.O. Box 22660
H. Vermeulen
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
H.Vermeulen@amc.uva.nl
Wetenschappelijk
P.O. Box 22660
H. Vermeulen
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
H.Vermeulen@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Abdominal surgery;
2. Age > 18;
3. ASA I-III;
4. Understanding the Dutch language;
5. Signed informed consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Cardiac diseases (NYHA > III en CCS > III);
2. Contraindications for epidural analgesia;
3. Presence of diabetes mellitus;
4. Planned for liver or oesophageal surgery;
5. Participating in another trial;
and/or anticipated postoperative stay in the Intensive Care Unit.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL588 |
| NTR-old | NTR644 |
| Ander register | : N/A |
| ISRCTN | ISRCTN16719551 |