Preterm infants are at risk for neurodevelopmental impairment, but also for obesity and risk factors of cardiometabolic diseases. Nutrition in the early neonatal phase and altered early growth might be predisposing these risks. Early body…
ID
Bron
Verkorte titel
Aandoening
Body composition (fat mass, fat free mass)
Preterm infants
Brain
Growth
Lichaamssamenstelling (vetmassa, vetvrije massa)
Te vroeg geboren kinderen
Hersenen
Groei
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Body composition (percentage fat mass and fat-free mass) measured using air-displacement plethysmography and neurodevelopmental outcome assessed using Bayley Scales for Infant and Toddler Development, third edition and eye-tracking at 2 years corrected age.
Achtergrond van het onderzoek
This observational non-invasive study, conducted in a level IV NICU in Rotterdam, the Netherlands, aims to elucidate the association between body composition and neurodevelopmental outcome up to two years of age in preterm born infants.
Doel van het onderzoek
Preterm infants are at risk for neurodevelopmental impairment, but also for obesity and risk factors of cardiometabolic diseases. Nutrition in the early neonatal phase and altered early growth might be predisposing these risks. Early body composition is considered a proxy for long-term metabolic health and may be associated with brain development.
This study aims to elucidate the association between neurodevelopmental outcome and body composition. We hypothesize fat mass and fat free mass are associated with neurodevelopmental outcome at two years of age in preterm born infants.
Onderzoeksopzet
NICU stay, term corrected age, 6 weeks, 6 months, 1 year and 2 year corrected age.
Onderzoeksproduct en/of interventie
not applicable
Publiek
Jorine A. Roelants
Rotterdam 3015 CN
The Netherlands
+31 10 7036015
j.roelants@erasmusmc.nl
Wetenschappelijk
Jorine A. Roelants
Rotterdam 3015 CN
The Netherlands
+31 10 7036015
j.roelants@erasmusmc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Preterm infants born before 30 weeks of gestation who are admitted to the NICU of the Erasmus MC within 48 hours after birth.
Written informed consent
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Severe congenital and chromosomal anomalies
2. Perinatal asphyxia (defined as 5’min APGAR score below 5 and cord blood pH below 7.00)
3. Severe brain injury (defined by intraventricular hemorrhage grade III or IV, venous infarction or periventricular leucomalacia gr II or higher )
4. Post hemorrhagic ventricular dilatation requiring lumbal punctures
5. Congenital TORCHES infections
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5757 |
| NTR-old | NTR6024 |
| Ander register | : MEC-2014-379 |