Recovery and survival of platelets in additive solution

Platelets in plasma can be stored for at least 7 days under blood bank conditions with

maintenance of in vitro and in vivo quality. The use of platelet additive solution (PAS) as

replacement for storage in plasma is attractive, as PASs are associated with about 50% fewer

allergic reactions post transfusion. Further, there is evidence that the newer generation PASs

have much better capability of maintaining the platelet quality, and are thought to be at least

equal to that in plasma. A number of alternative PASs are available (for example Composol,

Intersol and SSP+); not only do they preserve the platelet function better, they also provide a

margin in case safety technologies (like pathogen reduction methods) are applied that would

potentially reduce platelet shelf life.

The objectives of this study is to determine the recovery and survival of platelet concentrates;

in the first phase, a comparison will be made for platelet concentrates in plasma stored for 2-3

days versus those stored for 6-7 days; in the second phase, platelet concentrates stored for 6-7

days in Composol, Intersol and SSP+ (in about a 35%-plasma/65%-PAS ratio) will be

evaluated.

The recovery and survival of platelets stored in 3 different platelet additive solutions for 7 days is non inferior to the recovery and survival of platelets stored in plasma for 7 days

The standard of care in the Netherlands is 7 day storage of platelet concentrates in plasma or

in Intersol platelet additive solution (PAS). The intervention is that patients will receive

platelet concentrates in newer PASs, stored for 6-7 days.