Hypothesis: Subfertility is influenced by (low) chronic inflammation. Cytokine and microbiome profiling can be substantial in detecting the state of chronic inflammation and may thus help in solving subfertility.
ID
Bron
Verkorte titel
Aandoening
fertility problems
ongewenste kinderloosheid
Ondersteuning
Heerenveenseweg 99b
8471 ZA Wolvega
Netherlands
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
association between cytokine profile and subfertility<br>
association between vaginal microbiome and subfertility<br>
are cytokine profiles related to vaginal microbiome patterns?
Achtergrond van het onderzoek
In 20 normal fertile and 20 subfertile women visiting Nij Barrahus, fertility center a bloodsample and a vaginal swab will be taken at one specific moment in their treatment cycle (moment of IUI, scheduled 24-30H after a spontaneous LH surge).
Does cytokine and/or vaginal microbiome determinations reflect a specific profile, which can be attributed to a (low) chronic state of inflammation and therefore to a changed innate immune system?
Doel van het onderzoek
Hypothesis: Subfertility is influenced by (low) chronic inflammation. Cytokine and microbiome profiling can be substantial in detecting the state of chronic inflammation and may thus help in solving subfertility.
Onderzoeksopzet
Recruitment will end April 2016.
Onderzoeksproduct en/of interventie
none
Research subjects are treated with IUI (IntraUterine Insemination). After informed consent one time bloodsampling + one vaginal swab will be taken for determinations of respectively cytokines and microbiome profiling.
Publiek
J.P.W. Vermeiden
Heerenveenseweg 99b
[default] 8471 ZA
The Netherlands
Tel. 0561610030 Of 0646161592
j.vermeiden@xs4all.nl
Wetenschappelijk
J.P.W. Vermeiden
Heerenveenseweg 99b
[default] 8471 ZA
The Netherlands
Tel. 0561610030 Of 0646161592
j.vermeiden@xs4all.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
women with idiopathatic subfertility for a duration of 3 years and more (N=20)
lesbian couple and single mothers seeking to fulfill their childwish, with negative histories of cycle irregularity, STD's,, abdominal surgery. (N=20)
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. free of fever during the past month prior to study entry
2. free of antimicrobial interventions during the past month of study entry
3. positive CAT IgG sampling
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5286 |
| NTR-old | NTR5393 |
| Ander register | : |