Persons with a primary immune deficiency do have SARS-CoV-2 specific T-cells, neutralizing antibodies or both
ID
Bron
Verkorte titel
Aandoening
Primary Immune Deficiency
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. SARS-CoV-2 specific T-cell immunity: CD4+ T cells and CD8+ T cells against SARS-CoV-2 structural proteins (N, M and S)
2. SARS-CoV-2 specific neutralizing antibodies
Achtergrond van het onderzoek
Goal
Research has shown that persons who are immunocompromised due to different causes, have a higher risk for a severe clinical course of COVID-19. Nevertheless, scarce data in addition to our own experience suggest that persons with a primary immune deficiency, mainly common variable immune deficiency (CVID) do not have a higher risk for a severe clinical course. In this study, we will determine the SARS-CoV-2 specific T-cell and neutralizing antibody responses in persons with a primary immune deficiency who have had COVID-19 in the past months.
Population
Persons with a primary immune deficiency who are being monitored at the Leiden University Medical Center (LUMC) of 18 years or older, who have had COVID-19
Endpoints
SARS-CoV-2 specific T-cell immunity and SARS-CoV-2 neutralizing antibodies of persons with PID who have had COVID-19 compared to persons without PID who have had COVID-19
Doel van het onderzoek
Persons with a primary immune deficiency do have SARS-CoV-2 specific T-cells, neutralizing antibodies or both
Onderzoeksopzet
One time point during CVOID-19 or after having recovered from COVID-19
Onderzoeksproduct en/of interventie
None
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- age 18 or older
- diagnosed with primary immune deficiency and a patient at the Leiden University Medical Center
- proof of having had COVID-19 by PCR, either by GGD (municipal Health Center) of LUMC
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- vaccinated against SARS-CoV-2
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL9277 |
| Ander register | METC Leiden Den Haag Delft : N L76388.058.20 |