Pharmacokinetics of Lorazepam Oral Liquid in Paediatric ICU Patients

age between 2 weeks and 12 years,

signed consent from the parent or legal assent,

admitted to the paediatric ICU,

indwelling intravenous or arterial catheter,

scheduled to start the weaning protocol with oral lorazepam.

concomitant treatment with another investigational drug,

contraindications for lorazepam use;

Severe liver insufficiency, defined as 5 times upper level of ALAT and ASAT

Hypersensitivity to lorazepam,

Myasthenia gravis.