Endoscopic Tri-Modal Imaging (ETMI) for the detection of early neoplasia in patients with Barrett’s esophagus (BE) in tertiary referral centers; a randomized cross-over multi-center study.

Endoscopic Trimodal Imaging is a new imaging device that incorperates high-resolution white light endoscopy with autofluorescence imaging and narrow band imaging. Our aim of this study is to compare ETMI with standard video endoscopy for the detection of early neoplastic lesions in Barrett's esophagus. In this study high-risk patients reffered for the work-up of high-grade dysplasia or early cancer will included. All prodedures will performed by expert endoscopists in this field in 4 tertiary referal centres for the endoscopic treatment of early Barrett's neoplasia. All patients will undergo two endoscopies (ETMI and SVE) perfromed by two different endoscopists with an interval of 6-12 weeks.

ETMI improves the detection of early neoplasia in Barrett's esophagus.

In this study we will compare diagnostic endoscopy techniques for the detection of early enoplasia in Barrett's esophagus. These techniques are standard video endoscopy (the current standard) and
Endoscopic Tri-Modal Imaging (ETMI). Patients will undergo two consecutive endoscopies in an interval of 8-12 weeks. One of the two aformentioned techniques will be randomly assigned to the first procedure, the second procedure will subsequently be performed with the other technique by a second endoscopist.
The primary outcome will be the number of lesions and patients with early neoplasia detected with standard video endoscopy and ETMI.