We expect to find that tumor volume, as well as dynamic contrast enhanced MRI variables will be prognostic variables of treatment outcome
ID
Bron
Verkorte titel
Aandoening
Larynx and hypopharynx carcinoma
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The effect of imaging variables (e.g. apparent diffusion coefficient, tumor volume, and dynamic contrast enhanced MRI variables) on treatment outcome.
Achtergrond van het onderzoek
More and more laryngeal and hypopharyngeal patients receive larynx-preservation treatment instead of total laryngectomy (TLE). However, for some patients, treatments like primary radiotherapy might not be suitable and they risk undertreatment. This study aims to find imaging features on pretreatment imaging that predict outcome of radiotherapy in order to optimise patient selection for this treatment. This can help treatment decision making and increase survival rates.
Doel van het onderzoek
We expect to find that tumor volume, as well as dynamic contrast enhanced MRI variables will be prognostic variables of treatment outcome
Onderzoeksopzet
This is a retrospective study, we will gather clinical and treatment related data, as well as imaging from the time of diagnosis until last follow-up.
Onderzoeksproduct en/of interventie
Radiotherapy with or without chemotherapy
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Patients with larynx or hypopharynx carinoma primarily treated with radiotherapy with curative intent with or without additional chemotherapy. Treated in UMC Utrecht in the period of January 2008 and March 2020. Follow-up of at least 2 years or until recurrence. Available MRI imaging of the tumor site is made within 4 weeks before the start of the radiotherapy treatment.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
History of carcinoma at the time of diagnosis. Distant metastasis or second primary tumours at time of diagnosis.
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL9212 |
| Ander register | METC Utrecht : METC 20-340 |