Prescription of medication is the most common intervention in health care. Adherence to medication is often low. Non-adherence to long-term therapies severely compromises the effectiveness of treatment and thereby is a critical issue from both the…
ID
Bron
Verkorte titel
Aandoening
compliance, adherence, persistence, statins, bisphosphonates, antidepressants, RAS-inhibitors, BMQ, beliefs, SIMS
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The primary outcomes measured are taking-compliance measured over 365 days and the occurrence of complete discontinuation. Taking-compliance will be based on refill data and will be expressed as Proportion of days covered over a period of 365 days (12 months PDC). Differences in median proportion of days covered will be tested using the non-parametric Mann Whitney U test and the percentage of adherent patients between groups will be analyzed with χ2-test. Complete discontinuation will be defined as exceeding the permissible gap of 90 days within the one year observation period. Cox-proportional hazards will be used to compare discontinuation between intervention and control patients.
Achtergrond van het onderzoek
N/A
Doel van het onderzoek
Prescription of medication is the most common intervention in health care. Adherence to medication is often low. Non-adherence to long-term therapies severely compromises the effectiveness of treatment and thereby is a critical issue from both the perspective of quality of life of individual patients and from a public health perspective. Interventions aimed at improving adherence could increase both the effectiveness of medication and prevent the occurrence of adverse health outcomes. Counselling by telephone is a promising intervention to deliver patient-tailored care. In this study the effects of a counselling call at the start of the therapy will be investigated.
Onderzoeksopzet
Compliance and persistence will be assessed 12 months after the start of the therapie. Beliefs (BMQ) and satisfaction (SIMS) will be assessed 3 months after the start.
Onderzoeksproduct en/of interventie
A trained pharmacist or pharmacy technician calls patients by between 1 and 3 weeks after the start of therapy. The main purpose of this call is to evaluate the first two weeks, to explore factors that can negatively influence therapy, like drug related problems, beliefs or attitudes.
Publiek
Utrecht University<br>
Universiteitsweg 99<br>
P.O Box 80082
M.J. Kooij
Utrecht 3508 TB
The Netherlands
+31 (0)30 2537324
m.j.kooij@uu.nl
Wetenschappelijk
Utrecht University<br>
Universiteitsweg 99<br>
P.O Box 80082
M.J. Kooij
Utrecht 3508 TB
The Netherlands
+31 (0)30 2537324
m.j.kooij@uu.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Age over 18 years;
2. In posession of telephone;
3. Responsible for medication taking;
4. Receiving a first prescription in 12 months for a statin (C10), RAS-inhibitor (C09), Bisphosphonate (M05B) or antidepressant (N06A).
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Life expectancy of less than 6 months;
2. Receiving medication weekly (e.g. automated dispensing);
3. Not speaking the language of the pharmacist;
4. Not having a telephone.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL3089 |
| NTR-old | NTR3237 |
| Ander register | Institutional Review Board (IRB) : UP1019 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |