The aim of this study is to analyze the risk-factors associated with acquiring VIM-2 positive P. aeruginosa, among patients admitted to the Erasmus University Medical Center since the first recorded case in 2003. Secondary aims: 1.To…
ID
Bron
Aandoening
VIM-2 positive Pseudomonas aeruginosa
Healthcare-related/Gezondheidszorg gerelateerd
Multi-drug resistant/multiresistent
Risk factors/Risicofactoren
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
VIM-2 positive culture of P. auruginosa (infection or colonization)<br><br>
Absence of VIM-2 positive P. auruginosa (infection or colonization)/culture of P. auruginosa (infection or colonization)
Achtergrond van het onderzoek
Rationale: Since continuous outbreaks of VIM-2 positive P. aeruginosa occur in the Erasmus MC, additional research is needed to expand our knowledge of VIM-2 positive P. aeruginosa transmission and to identify risk factors applicable to the Erasmus MC, so we can implement targeted prevention strategies in order to stop the outbreaks.
Objective: The main aim of this study is to analyze the risk-factors associated with acquiring VIM-2 positive P. aeruginosa, among patients admitted to the Erasmus University Medical Center since the first recorded case in 2003. The secondary aim is to investigate whether there is a difference in risk-factors between ICU and non-ICU patients in the Erasmus Medical Center. Also, to investigate whether Diversilab types are associated with specific risk-factors.
Study design: Case-control study (observational)
Study population: The population consist of adult patients (>=18years) admitted to the Erasmus MC
Main study parameters/endpoints: The main outcomes are: VIM-2 positive culture after 48 hours after admittance in the Erasmus MC (Colonization and infection) and VIM-2 negative colonization and infection
Doel van het onderzoek
The aim of this study is to analyze the risk-factors associated with acquiring VIM-2 positive P. aeruginosa, among patients admitted to the Erasmus University Medical Center since the first recorded case in 2003.
Secondary aims:
1.To investigate whether there is a difference in risk-factors between ICU and non-ICU patients in the Erasmus Medical Center. If that is the case, what are those differences?
2.To investigate whether Diversilab types are associated with specific risk-factors.(E.g. Diversilab types can be associated with medical materials used on various wards (ICU/non-ICU); prior carbapenem use; patient characteristics like age and sex etc.). (For example, males over the age of 50 have a higher odds (x) of acquiring Diversilab type B… when admitted on the ICU.. when having a urinary catheter and so on).
Onderzoeksopzet
The time period in which cases are identified ranges from August 2003 till April 2015.
Onderzoeksproduct en/of interventie
Not applicable
Publiek
Margreet C. Vos
Wytemaweg 80, Room Na-901k
Rotterdam 3015 CN
The Netherlands
0107033510
m.vos@erasmusmc.nl
Wetenschappelijk
Margreet C. Vos
Wytemaweg 80, Room Na-901k
Rotterdam 3015 CN
The Netherlands
0107033510
m.vos@erasmusmc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• VIM-2 positive culture after 48 hours after admittance in the Erasmus University Medidcal Center.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• Children, because they are admitted at the Sophia Children’s Hospital and are separated from the Erasmus MC facilities. To our knowledge, there is no evidential cross-over potential of VIM-2 positive P. aeruginosa to the adult-care facilities.
• The outbreak resulting from Endoscopic Retrograde Cholangiopancreatography (ERCP). This outbreak has a known cause and is therefore reported and investigated separately (21).
• Patients only admitted at the Erasmus MC Cancer Institute . These patients are cared for in a separate building of the Erasmus MC and are therefore not be included in this study.
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4874 |
| NTR-old | NTR5145 |
| Ander register | : MEC-2015-240 |